Toxicarioside A inhibits SGC-7901 proliferation, migration and invasion via NF-κB/bFGF signaling

Table 1 The inhibition rates of human gastric cancer cell line cells treated with different concentrations of toxicarioside A for different time intervals

Groups	24 h		48 h
	A value	Inhibitory rate (%)	A value	Inhibitory rate (%)
Control	0.879 ± 0.048	0.00 ± 0.00	0.932 ± 0.036	0.00 ± 0.00
Toxicarioside A (μg/mL)
0.5	0.793 ± 0.062	9.79 ± 7.63	0.752 ± 0.073	19.13 ± 5.38
1.5	0.646 ± 0.041	27.83 ± 4.78a	0.596 ± 0.113	36.19 ± 3.81a
4.5	0.528 ± 0.078	40.18 ± 3.32a	0.443 ± 0.056	49.32 ± 5.17b
9.0	0.352 ± 0.092	61.84 ± 6.61b	0.301 ± 0.049	66.94 ± 7.03b

Data representative of six independent experiments were expressed as mean ± SE.

^aP < 0.05,

^bP < 0.01 vs control group.

Table 2 Effect of toxicarioside A on cell migration and invasion

Groups	Dose (μg/mL)	Migration		Invasion
		Cell number	Inhibition rate (%)	Cell number	Inhibition rate (%)
Control	0.0	69.40 ± 6.38	0.00 ± 0.00	65.60 ± 7.20	0.00 ± 0.00
Toxicarioside A	0.5	62.50 ± 8.90	10.01 ± 9.78	57.80 ± 4.32	10.89 ± 8.64
	1.5	54.80 ± 7.30	22.38 ± 10.64a	49.70 ± 5.68	24.03 ± 9.06a
	4.5	41.60 ± 5.88	39.58 ± 11.62a	36.40 ± 7.94	44.68 ± 9.19a
	9.0	35.80 ± 8.32	48.13 ± 10.12b	30.10 ± 6.46	54.38 ± 8.17b

Data representative of three independent experiments were expressed as mean ± SE.

^aP < 0.05,

^bP < 0.01 vs control group.