Risk for gastric neoplasias in patients with chronic atrophic gastritis: A critical reappraisal

Table 1 Prevalence of chronic atrophic gastritis

Author	Year	Country	Study type	Patients	Age (yr)	CAG (%)
Serology
Sipponen et al[14]	2003	Finland	General population	12 252 (men)	51-65	5.2
Green et al[15]	2005	New Zealand	General population	466	> 65	6.7
Weck et al[16]	2007	Germany	General population	9444	50-74	6
Telaranta-Keerle et al[17]	2010	Finland	General population	4256	18-92	3.5
Histology
Oksanen et al[18]	2000	Finland	Endoscopic cohort	207	19-83	131
Borch et al[19]	2000	Sweden	General Population	501	35-85	9.42
Asaka et al[20]	2001	Japan	General Population	2455	< 20 to > 70	55.53
Redéen et al[21]	2003	Sweden	General Population	488	37-85	9
Storskrubb et al[22]	2008	Sweden	General Population	976	20-80	6.64
Zou et al[23]	2011	China	General Population	1022	18-80	63.83

¹This percentage refers to patients (n = 27) with atrophic body gastritis;

²this percentage refers to patients (n = 47) with atrophic pangastritis and corpus- predominant (gastritis;

³these percentages included chronic atrophic gastritis (CAG) diagnosis irrespective of the atrophy localization in the gastric mucosa (antrum and/or corpus);

⁴this percentage refers to patients (n = 54) with multifocal atrophic gastritis and atrophic corpus- limited gastritis.

Table 2 Incidence of gastric cancer in patients with chronic atrophic gastritis or pernicious anemia

Author	Year	Country	Study type	Patients	Age, median or range (yr)	GC	Annual incidence of GC, person-year (%)
Patients with chronic atrophic gastritis
Walker et al[25]	1971	Australia	Retrospective	40	40-64	4 (10)	0.6
Ectors et al[26]	1986	United Kingdom	Retrospective	225	-	3 (1.3)	0.1
Tatsuta et al[27]	1993	Japan	Retrospective	654	-	22 (3.4)	0.2
You et al[28]	1999	China	Prospective	20821	35-64	19 (0.9)	0.2
Whiting et al[29]	2002	United Kingdom	Prospective	1042	> 40	12 (11.5)	1.1
Dinis-Ribeiro et al[30]	2004	Portugal	Retrospective	1771	-	4 (2.2)	0.7
Lahner et al[31]	2005	Italy	Prospective	106	22-74	1 (0.9)	0.1
de Vries et al[32]	2008	Netherlands	Retrospective	84 0722	65.7	1035 (1.2)	0.2
Vannella et al[33]	2010	Italy	Retrospective	300	18-78	3 (1)	0.2
Patients with pernicious anemia
Borch et al[34]	1986	Sweden	Prospective	61	-	0	0
Kokkola et al[35]	1998	Finland	Prospective	62	20-73	2 (3.2)	1.10
Sjöblom et al[36]	1993	Finland	Prospective	56	27-78	2 (3.5)	1.20
Armbrecht et al[37]	1990	United Kingdom	Prospective	27	26-81	0	0
Bresky et al[38]	2003	Spain	Prospective	68	-	0	0
Ye et al[39]	2003	Sweden	Retrospective	21 265	74.3	177 (0.8)	0.10
Vannella et al[33]	2010	Italy	Retrospective	129	23-74	2 (1.5)	0.30

¹This number refers to biopsies taken in 144 patients and includes chronic atrophic gastritis (CAG) with type I, II, III intestinal metaplasia;

²this number refers to CAG patients with or without intestinal metaplasia. GC: Gastric cancer.