Bacterial flora concurrent with Helicobacter pylori in the stomach of patients with upper gastrointestinal diseases

Table 1 Non-Helicobacter pylori bacterial cultures of gastric biopsies

Micro-organism	Culture condition1			Colonized	Urease activity3	Gram stain
	I	II	III	patients (n)2
Streptococcus				(54)		G+
Streptococcus pneumoniae	3	10		11
Streptococcus salivarius	10	9		16
Streptococcus anginosus		3		3
Streptococcus oralis		2		2
Streptococcus cristatus	1			1
Streptococcus gordonii	2			2
Streptococcus vestibularis	1			1
Streptococcus spp.	10	13		18
Neisseria				(32)		G-
Neisseria flavescens	11	16	11	23
Neisseria perflava	2	1	1	3
Neisseria macacae		1		1
Neisseria sicca	1			1
Neisseria spp.	3	1		4
Rothia				(29)		G+
Rothia mucilaginosa	6	10		15
Rothia dentocariosa		3	1	4
Rothia aeria	1			1
Rothia spp.	4	7		9
Staphylococcus				(21)		G+
Staphylococcus epidermidis	3	3		5	5
Staphylococcus aureus	3	4		5	3
Staphylococcus capitis		3		3	1
Staphylococcus warneri	2	1		3	3
Staphylococcus cohnii		2		2
Staphylococcus haemolyticus		1		1
Staphylococcus spp.		2		2
Lactobacillus				(9)		G+
Lactobacillus salivarius			4	4
Lactobacillus oris			2	2
Lactobacillus fermentum			1	1
Lactobacillus spp.		1	1	2
Corynebacterium				(4)		G+
Corynebacterium argentoratense	2	1		3
Corynebacterium propinquum	1	1		1
Kingella				(3)		G-
Kingella denitrificans			2	2
Kingella spp.			1	1
Others
Capnocytophaga ochracea			3	3		G-
Haemophilus parainfluenzae		1	1	2		G-
Acinetobacter lwoffii	2			2		G-
Klebsiella pneumoniae	1			1	1	G-
Cardiobacterium sp			1	1		G-
Actinomyces spp.		2		2		G+
Micrococcus luteus	1			1		G+
Weissella confusa			1	1		G+
Aerococcus spp.	1			1		G+
Bacillus spp.	1			1		G+
Brevibacterium spp.		1		1	1	G+
Total	72	99	30	168

¹The number of bacterial strains isolated inI: Columbia blood agar incubated under aerobic condition; II: Columbia blood agar incubated under microaerophilic condition; III: Campylobacter agar under microaerophilic condition;

²The number of patients colonized by the same genus is shown in parentheses;

³The number of bacterial isolates with urease activity.

Table 2 Demographic, non-Helicobacter pylori bacterial colonization and clinical characteristics of 103 patients

Diseases	Enrolled patients (n)	Age (yr)1	Gender (male:female)	Colonized patients
Duodenal ulcer	42	39 (20-56)	2:1	28 (66.7%)
Gastric ulcer	21	42 (20-62)	0.75:1	9 (42.9%)
Gastritis	23	39 (10-75)	0.44:1	13 (56.5%)
Non-ulcer dyspepsia	13	34 (22-57)	0.63:1	13 (100%)a
Reflux esophagitis	4	52 (41-63)	1:1	4 (100%)
Total	103	39 (10-75)	0.96:1	67 (65.0%)
P value		0.0792	0.0743	0.00284

¹Data are expressed as median (range);

²By analysis of variance;

³By χ² test;

⁴By Fisher exact test;

^aP = 0.00006 vs gastric ulcer group by Bonferroni method.