Octreotide ameliorates gastric lesions in chronically mild stressed rats

Table 1 Effect of octreotide on ulcer index and plasma corticosterone level in chronic mild stressed rats

Groups	Parameters
	Ulcer index (mm)	Plasma corticosterone (μg/dL)
Control	0 ± 0	15.4 ± 1.0
OCT (50 μg/kg)	0 ± 0	17.3 ± 0.7
OCT (90 μg/kg)	0 ± 0	16.0 ± 1.2
CMS	6.4 ± 0.16a	28.4 ± 0.6a
CMS + OCT (50 μg/kg)	2.4 ± 0.06a,b	17.2 ± 0.7b
CMS + OCT (90 μg/kg)	0.6 ± 0.01a,b	20.4 ± 1.1b

Rats were subjected to mild stressors for 21 d; octreotide was given 2 h before the insults or to normal animals. Data are mean of 6-8 rats ± SE.

^a,bP < 0.05 compared to control and chronic mild stress (CMS) groups respectively. For comparisons among treatment groups, one-way ANOVA followed by Tukey-Kramer Multiple Comparisons Test was used. OCT: Octreotide.