Association between acute pancreatitis and peptic ulcer disease

Table 1 Characteristics of the patients with or without peptic ulcer disease (mean ± SE) n (%)

	Ulcer (n = 41)	No ulcer (n = 37)	P value
Age (yrs)	56.6 ± 2.3	49.8 ± 2.9	0.07
Gender
Male	32 (78.0)	20 (54.1)	0.03
Female	9 (22.0)	17 (45.9)
BMI (kg/m2)	23.9 ± 0.5	23.3 ± 0.8	0.48
Diabetes
Yes	7 (17.7)	3 (8.1)	0.31
No	34 (82.9)	34 (91.9)
Hypertension
Yes	9 (22.0)	6 (16.2)	0.52
No	32 (78.0)	31 (83.8)
Etiology
Alcohol	22 (53.7)	9 (24.3)	0.03
Biliary stone	7 (17.1)	9 (24.3)
Idiopathic	6 (14.6)	14 (37.8)
Others	6 (14.6)	5 (13.5
Smoke
Yes	20 (48.8)	10 (27.0)	0.05
No	21 (51.2)	27 (73.0)
Alcohol
Yes	29 (70.7)	16 (43.2)	0.01
No	12 (29.3)	21 (56.8)
Laboratory
BUN (mg/dL)	17.2 ± 1.6	17.9 ± 1.7	0.78
Cr (mg/dL)	1.1 ± 0.1	1.0 ± 0.1	0.34
Amylase (IU/L)	633.9 ± 123.0	564.3 ± 77.9	0.64
Lipase (IU/L)	405.1 ± 75.2	518.5 ± 82.6	0.31
Triglyceride (mg/dL)	261.5 ± 71.5	111.0 ± 15.6	0.05
ESR (mm/h)	46.6 ± 5.5	36.3 ± 4.6	0.16
CRP (mg/dL	15.5 ± 2.3	5.2 ± 0.9	< 0.001
CTSI	2.1 ± 0.3	1.6 ± 0.2	0.21
Ranson score
On admission	1.3 ± 0.2	1.2 ± 0.2	0.76
At 48 h	0.8 ± 0.2	0.4 ± 0.1	0.07
APACHE II score	8.0 ± 0.7	4.5 ± 0.7	0.001
< 6	15 (36.6)	29 (78.4)	< 0.001
≥ 6	26 (63.4)	8 (21.6)
Time to endoscopy (d)	3.5 ± 0.5	3.0 ± 0.4	0.45
Death	0 (0)	0 (0)

BMI: Body mass index; BUN: Blood urea nitrogen; Cr: creatinine; ESR: Erythrocyte sedimentation rate; CRP: C-reactive protein; CTSI: Computed tomography severity index; APACHE: Acute Physiology and Chronic Health Evaluation.

Table 2 Risk factors for peptic ulcer in patients with acute pancreatitis (multivariate analysis)

Variables	OR	95% CI	P value
Alcohol-induced	3.23	0.77-14.29	0.11
Smoking	2.86	0.65-12.5	0.16
APACHE II score ≥ 6	7.69	1.78-33.33	< 0.01

OR: Odds ratio; CI: Confidence interval; APACHE: Acute Physiology and Chronic Health Evaluation.

Table 3 Infection rate of Helicobacter pylori in the patients with peptic ulcer disease (mean ± SE) n (%)

	H. pylori-positive	H. pylori-negative	P value
n (%)	13 (31.7)	28 (68.3)
Age (yrs)	61.2 ± 4.5	54.5 ± 2.5	0.17
Gender
Male	10 (76.9)	22 (78.8)	0.91
Female	3 (23.1)	6 (21.4)
BMI (kg/m2)	24.1 ± 1.1	23.8 ± 0.6	0.76
Smoke
Yes	7 (53.8)	14 (50.0)	0.82
No	6 (46.2)	14 (50.0)
Alcohol
Yes	8 (61.5)	21 (75.0)	0.38
No	5 (38.5)	7 (25.0)
Location of ulcer
GU only	10 (76.9)	12 (42.9)	0.02
DU only	0	12 (42.9)
GU and DU	3 (23.1)	4 (14.3)

H. pylori: Helicobacter pylori; BMI: Body mass index; GU: Gastric ulcer; DU: Duodenal ulcer.