Vascular endothelial growth factor 165b expression in stromal cells and colorectal cancer

Table 1 Characteristics of patients

	n	%
Gender
Female	75	45.5
Male	90	54.5
Primary tumor location
Ascending colon	29	17.6
Transverse colon	18	10.9
Descending colon	6	3.6
Sigmoid colon	30	18.2
Rectum	82	49.7
TNM stage
0	9	5.5
I	16	9.7
II	55	33.3
III	66	40.0
IV	19	11.5
T factor
Tis	9	5.5
T1	7	4.2
T2	25	15.2
T3	111	67.3
T4	13	7.9
Histological differentiation
Well	47	28.5
Moderate	95	57.6
Poor	8	4.8
Mucinous	10	6.1
Other	5	3.0
Venous invasion
v0	46	27.9
v1	73	44.2
v2	32	19.4
v3	14	8.5
Lymphatic invasion
ly0	53	32.1
ly1	79	47.9
ly2	28	17.0
ly3	5	3.0
Recurrence except stage IV cases
No	95	65.1
Yes	51	34.9

Table 2 Association between vascular endothelial growth factor-A expression and clinicopathological characteristics n (%)

	n	Tumor VEGF positive cases	Stromal VEGF positive cases
TNM stage
0	9	1 (11.1)	7 (77.8)
I	16	2 (12.5)	6 (37.5)
II	55	32 (58.2)	33 (60.0)
III	66	38 (57.6)	22 (33.3)
IV	19	16 (84.2)	5 (26.3)
Total	165	89 (53.9)	73 (44.2)
		P < 0.0001	P = 0.004
T factor
Tis	9	1 (11.1)	7 (77.8)
T1	7	0 (0.0)	6 (85.7)
T2	25	9 (36.0)	11 (44.0)
T3	111	70 (63.1)	45 (40.5)
T4	13	9 (69.2)	4 (30.8)
Total	165	89 (53.9)	73 (44.2)
		P = 0.0002	P = 0.01
Histological differentiation
Well	47	15 (31.9)	23 (48.9)
Moderate	95	63 (66.3)	41 (43.2)
Poor	8	3 (37.5)	4 (50.0)
Mucinous	10	5 (50.0)	2 (20.0)
Other	5	1 (20.0)	3 (60.0)
		NS	NS
Venous invasion
v0	46	14 (30.4)	27 (58.7)
v1	73	43 (58.9)	29 (39.7)
v2	32	23 (71.9)	15 (46.9)
v3	14	9 (64.3)	2 (14.3)
		P = 0.001	P = 0.015
Lymphatic invasion
ly0	53	16 (30.1)	26 (49.1)
ly1	79	48 (60.8)	39 (49.4)
ly2	28	20 (71.4)	7 (25.0)
ly3	5	5 (100.0)	1 (20.0)
		P < 0.0001	P = 0.04

NS: Not significant; VEGF: Vascular endothelial growth factor.

Table 3 Logistic regression analysis for recurrence in colorectal carcinoma except for stage IV cases

Factor	n (Recurrence)	Univariate analysis			Multivariate analysis
		Relative risk	95% CI	P value	Relative risk	95% CI	P value
Clinical stage
0	9(1)	2.120	1.302-3.451	0.0250	1.718	0.980-3.010	0.0586
I	16(3)
II	55(15)
III	66(32)
Venous invasion
v0	46(12)	1.500	1.050-2.143	0.0260	0.812	0.504-1.307	0.3907
v1	63(27)
v2	27(6)
v3	10(6)
Lympathic invasion
ly0	52(13)	2.094	1.354-3.238	0.0010	1.27	0.714-2.261	0.4155
ly1	68(24)
ly2	23(12)
ly3	3(2)
s-VEGF-A positive	68(14)	0.269	0.135-0.535	0.0002	0.309	0.141-0.676	0.0033
t-VEGF-A positive	73(31)	2.340	1.218-4.495	0.0110	1.918	0.768-3.718	0.1918
Total	146(51)

CI: Confidence interval.