De novo combination therapy with lamivudine and adefovir dipivoxil in chronic hepatitis B patients

doi:10.3748/wjg.v17.i43.4804

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2011; 17(43): 4804-4809
Published online Nov 21, 2011. doi: 10.3748/wjg.v17.i43.4804

Table 1 Characteristics of patients at baseline, median (min-max)

Characteristic	De novo combination group (n = 10)	Add-on combination group (n = 20)	P value
Age (yr)	45.6 ± 8.2	45.2 ± 8.2	0.89
Gender (males,%)	6 (60%)	11 (55%)	1
Height (m)	1.7 ± 0.7	1.7 ± 0.9	0.58
Weight (kg)	68.9 ± 9.7	67.3 ± 10.5	0.69
BMI (kg/m²)	23.8 ± 1.8	23.7 ± 1.6	0.88
HBV DNA levels (log₁₀, copies/mL)	6.23 ± 0.91	6.43 ± 0.95	0.58
Serum ALT (IU/L)	124 (82-156)	283 (187-321)	0
Serum TBIL (μmol/L)	49.5 (23-72)	73.5 (49.0-99.6)	0.001
Serum ALB (g/L)	29.75 (25.40-34.00)	26.65 (23.00-32.00)	0.021
Child-Pugh score	11 (9-13)	11 (9-13)	0.809
Red blood cell counts (× 10¹²/L)	3.6 (3.0-4.5)	3.3 (1.9-5.0)	0.234
HB (g/L)	106 (90-120)	97 (75-115)	0.059
White blood cell counts (× 10⁹/L)	3.85 (2.70-6.80)	3.75 (1.90-6.00)	0.657
Blood PLT count (× 10⁹/L)	96 (76-150)	96 (50-112)	0.657
Serum BUN (mmol/L)	6.05 (3.70-8.10)	4.35 (1.90-8.50)	0.139
Serum Cr (μmol/L)	99.5 (77.0-145.0)	77.0 (40.0-156.0)	0.024

BMI: Body mass index; HBV: Hepatitis B virus; ALT: Alanine aminotransferase; TBIL: Total bilirubin; ALB: Albumin; HB: Hemoglobin; PLT: Platelet; BUN: Blood urine nitrogen; Cr: Creatinine.

Table 2 Biochemical responses of the patients, median (min-max)

	De novo combination group (n = 10)					Add-on combination group (n = 20)
	2 wk before combination treatment	4 wk after combination treatment	12 wk after combination treatment	24 wk aftercombinationtreatment	48 wk after combination treatment	2 wk before combination treatment	4 wk after combination treatment	12 wk after combination treatment	24 wk after combination treatment	48 wk after combination treatment
Child-Pugh score	11 (9-13)	10 (8-12)	10 (8-12)	9 (7-11)^c	7 (6-9)^c^a	11 (9-13)	10 (9-12)	10 (9-12)	10 (7-11)^c	9 (7-10)^c
Serum ALT (IU/L)	124 (82-156)^a	111 (80-141)^a	109 (69-125)^a	89 (59-112)^c^a	49 (28-67)^c^a	283 (187-321)	251 (171-302)^c	218 (146-277)^c	173 (105-239)^c	105 (65-186)^c
Serum TBIL (μmol/L)	49.5 (23-72)^a	47.3 (25.0-70.1)^a	41.3 (25.5-63.0)^a	37.8 (22.5-57.4)^c^a	31.0 (22.0-41.0)^c^a	73.5 (49.0-99.6)	68.3 (44.5-88.7)	63.5 (35.8-79.0)^c	56.7 (32.0-72.3)^c	41.2(29.0-58.1)^c
Serum ALB (g/L)	29.75(25.40-34.00)^a	30.15(27.20-34.10)^a	30.55(27.60-33.00)^a	32.80(29.00-35.00)^c^a	34.00(30.00-37.00)^c^a	26.65(23.00-32.00)	28.20(25.60-32.90)	27.85(25.00-31.90)	28.75(25.50-33.00)^c	30.5(28.0-34.8)^c

^aP < 0.05 vs add-on combination group;

^cP < 0.05 vs 2 wk before combination treatment in the same group. ALT: Alanine aminotransferase; TBIL: Total bilirubin; ALB: Albumin.

Table 3 Blood cell counts and renal function of the patients, median (min-max)

	De novo combination group (n = 10)					Add-on combination group (n = 20)
	2 wk before combination treatment	4 wk after combination treatment	12 wk after combination treatment	24 wk after combination treatment	48 wk after combination treatment	2 wk before combination treatment	4 wk after combination treatment	12 wk after combination treatment	24 wk after combination treatment	48 wk after combination treatment
Red blood cell counts (× 10¹²/L)	3.6 (3.0-4.5)	3.4 (3.0-4.3)	3.5 (2.9-4.1)	3.6 (3.1-4.0)^a	3.8 (3.0-5.1)^a	3.3 (1.9-5.0)	3.2 (2.3-4.1)	3.1 (2.5-4.0)	3.1 (2.5-3.9)	3.1 (2.7-3.4)^c
HB (g/L)	106 (90-120)	104 (92-113)^a	102 (99-115)	107 (94-114)^a	105 (85-121)^a	97 (75-115)	95 (80-114)	95 (85-111)	99 (88-112)	97 (84-105)
White blood cell counts (× 10⁹/L)	3.85 (2.70-6.80)	3.90 (2.90-5.70)	3.80 (3.00-5.20)	3.95 (3.20-4.70)	4.00 (3.00-4.50)	3.75 (1.90-6.00)	3.75 (2.50-5.60)	3.70 (2.90-5.00)	3.75 (2.90-4.70)	3.85 (3.00-5.10)
Blood PLT counts (× 10⁹/L)	96 (76-150)	90 (72-100)	94 (70-116)	95 (68-108)	98 (72-103)	96 (50-112)	94 (63-111)	92 (76-110)	90 (69-107)	93 (73-112)
Serum BUN (mmol/L)	6.05 (3.70-8.10)	5.90 (3.00-7.40)	5.65 (3.60-7.10)	5.50 (2.50-6.80)	5.45 (3.30-7.00)	4.35 (1.90-8.50)	5.25 (2.20-8.70)	5.00 (2.20-8.00)	5.00 (2.90-7.50)	4.95 (2.30-7.10)
Serum Cr (μmol/L)	99.5 (77.0-145.0)^a	96.5 (76.0-141.0)	96.0 (69.0-112.0)	78.0 (56.0-99.0)^c	78.5 (61.0-107.0)^c	77.0 (40.0-156.0)	95.5 (61.0-124.0)	86.0 (68.0-131.0)	73.5 (42.0-132.0)	79.0 (41.0-132.0)

^aP < 0.05 vs add-on combination group;^cP < 0.05 vs 2 wk before combination treatment in the same group. HB: Hemoglobin; PLT: Platelet; BUN: Blood urine nitrogen; Cr: Creatinine.

Citation: Fan XH, Geng JZ, Wang LF, Zheng YY, Lu HY, Li J, Xu XY. De novo combination therapy with lamivudine and adefovir dipivoxil in chronic hepatitis B patients. World J Gastroenterol 2011; 17(43): 4804-4809
URL: https://www.wjgnet.com/1007-9327/full/v17/i43/4804.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i43.4804