Silence of HIN-1 expression through methylation of its gene promoter in gastric cancer

Table 1 Association of high in normal-1 methylation with clinicopathologic characteristics in gastric cancer

Variable	Patients	HIN-1 methylation	P value
Sex			0.161
Male	32	17
Female	13	9
Age (yr)			0.401
≤ 50	14	9
> 50	31	17
Tumor size (cm)			0.283
< 5	25	16
≥ 5	19	10
Tumor differentiation			0.000a
Moderate/poor	21	17
Well	23	8
Stage			0.683
I-II	13	7
III-IV	29	17
Nodal status			0.903
-	9	5
+	35	20

^aPearson’s χ² test using SPSS 13.0 software for Windows. The methylation frequency of well-differentiated tumor vs moderately/poorly tumor. TNM was staged according to the guidelines of the International Union against Cancer. HIN-1: High in normal-1.