Two clinically relevant pressures of carbon dioxide pneumoperitoneum cause hepatic injury in a rabbit model

Table 1 Changes in liver function (mean ± SD)

Group	TB	ALT	AST	A	Pre-A
Control	1.5 ± 0.3	52.4 ± 9.6	41.0 ± 9.1	32.6 ± 2.1	154.5 ± 17.7
10 mmHg	1.6 ± 0.3	77.3 ± 14.5a	60.1 ± 11.4a	31.7 ± 2.0	146.9 ± 15.7
15 mmHg	1.7 ± 0.5	165.1 ± 19.4a	103.8 ± 12.3a	30.5 ± 1.5	118.0 ± 14.9a

^aP < 0.05 vs control group. TB: Total bilirubin; ALT: Alanine transaminase; AST: Aspartate transaminase; A: Albumin; Pre-A: Pre-albumin.

Table 2 Activity of adenine nucleotide translocator in liver mitochondria (mean ± SD)

Group	ANT (9-10 mol/min per g protein)
Control	10.83 ± 1.11
10 mmHg	9.03 ± 0.89
15 mmHg	6.64 ± 0.77a

^aP < 0.05 vs control group; ANT: Adenine nucleotide translocator.