Detection of Helicobacter pylori: A faster urease test can save resources

doi:10.3748/wjg.v17.i3.349

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Jan 21, 2011 (publication date) through Feb 11, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2011; 17(3): 349-353
Published online Jan 21, 2011. doi: 10.3748/wjg.v17.i3.349

Table 1 Sensitivity, specificity and predictive values for Campylobacter-like organism test and Quick test (all patients)

Test (at 24 h)	True positive	True negative	Total
CLO test
Positive	40	1	41
Negative	0	144	144
Quick test
Positive	39	1	40
Negative	1	144	145

Campylobacter-like organism (CLO) test: sensitivity 100% [95% confidence interval (CI): 91.24-100], specificity 99.3% (95% CI: 96.2-99.88), positive predictive value (PPV) 97.6% (95% CI: 87.4-99.57), negative predictive value (NPV) 100% (95% CI: 97.4-100); Quick test: sensitivity 97.5% (95% CI: 87.12-99.56), specificity 99.3% (95% CI: 96.2-99.88), PPV 97.5% (95% CI: 87.12-99.56), NPV 99.3% (95% CI: 96.2-99.88).

Table 2 Sensitivity, specificity and predictive values of the Campylobacter-like organism and Quick tests in Group 1

Test (at 24 h)	True positive	True negative	Total
CLO test
Positive	26	0	26
Negative	0	79	79
Quick test
Positive	25	0	25
Negative	1	79	80

Campylobacter-like organism (CLO) test: sensitivity 100% [95% confidence interval (CI): 87.13-100], specificity 100% (95% CI: 95.36-100), positive predictive value (PPV) 100% (95% CI: 87.13-100), negative predictive value (NPV) 100% (95% CI: 95.36-100); Quick test: sensitivity 96.1% (95% CI: 81.11-99.32), specificity 100% (95% CI: 95.36-100), PPV 100% (95% CI: 86.68-100), NPV 98.7% (95% CI: 93.25-99.78).

Table 3 Sensitivity, specificity and predictive values of the Campylobacter-like organism and Quick tests in Group 2

Test (at 24 h)	True positive	True negative	Total
CLO test
Positive	14	1	15
Negative	0	65	65
Quick test
Positive	14	1	15
Negative	0	65	65

Campylobacter-like organism (CLO) test: sensitivity 100% [95% confidence interval (CI): 78.47-100], specificity 98.5% (95% CI: 91.9-99.73), positive predictive value (PPV) 93.3% (95% CI: 70.18-98.81), negative predictive value (NPV) 100% (95% CI: 94.42-100); Quick test: sensitivity 100% (95% CI: 78.47-100), specificity 98.5% (95% CI: 91.9-99.73), PPV 93.3% (95% CI: 70.18-98.81), NPV 100% (95% CI: 94.42-100).

Table 4 Number of patients with a positive Campylobacter-like organism and Quick test at 2 min, 30 min, 2 h, 24 h for Groups 1 and 2

Time	Group 1		Group 2
	CLO test	Quick test	CLO test	Quick test
2 min	2	5	0	3
30 min	13^a	20^a	4	8
2 h	23	25	11	14
24 h	26	25	15	15

^aP = 0.02. CLO test: Campylobacter-like organism test.

Table 5 Number of patients with a positive Campylobacter-like organism and Quick test at 2 min, 30 min, 2 h, 24 h (all patients)

Time	CLO test	Quick test	P-value
2 min	2	8	0.03
30 min	17	28	0.05
2 h	34	39	0.28
24 h	41	40	0.45

CLO test: Campylobacter-like organism test.

Citation: Koumi A, Filippidis T, Leontara V, Makri L, Panos MZ. Detection of Helicobacter pylori: A faster urease test can save resources. World J Gastroenterol 2011; 17(3): 349-353
URL: https://www.wjgnet.com/1007-9327/full/v17/i3/349.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i3.349