Yu L, Wang CY, Xi B, Sun L, Wang RQ, Yan YK, Zhu LY. GST polymorphisms are associated with hepatocellular carcinoma risk in Chinese population. World J Gastroenterol 2011; 17(27): 3248-3256 [PMID: 21912475 DOI: 10.3748/wjg.v17.i27.3248]
Corresponding Author of This Article
Li-Ying Zhu, MD, PhD, Department of Infectious Disease, the Fourth Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China. zlyhmu@163.com
Article-Type of This Article
Brief Article
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Table 3 Subgroup analysis of the association between GSTM1 polymorphism and hepatocellular carcinoma risk
Group
No. of studies (cases/controls)
Statistical method
OR (95% CI)
P
All studies
19 (2660/4017)
Random
1.487 (1.159-1.908)
0.002
Residence area of the subjects
High-incidence area
11 (1510/2666)
Random
1.659 (1.264-2.177)
0.000
Low-incidence area
7 (1040/1239)
Random
1.235 (0.753-2.026)
0.402
Mixed areas
1 (110/112)
-
1.602 (0.943-2.721)
0.081
No. of cases
< 100
9 (651/1262)
Random
1.676 (1.061-2.649)
0.027
≥ 100
10 (2009/2755)
Random
1.365 (1.005-1.853)
0.046
Source of controls
Population-based
9 (1489/1548)
Random
1.316 (0.915-1.892)
0.139
Hospital-based
10 (1171/2469)
Random
1.675 (1.251-2.243)
0.001
Table 4 Subgroup analysis of the association between GSTT1 polymorphism and hepatocellular carcinoma risk
Group
No. of studies (cases/controls)
Statistical method
OR (95% CI)
P
All studies
16 (2410/3669)
Random
1.510 (1.236-1.845)
0.000
Residence area of the subjects
High-incidence area
10 (1418/2489)
Random
1.641 (1.328-2.027)
0.000
Low-incidence area
5 (882/1068)
Random
1.152 (0.777-1.707)
0.483
Mixed areas
1 (110/112)
-
2.234 (1.305-3.825)
0.003
Number of cases
< 100
7 (502/949)
Random
1.617 (1.035-2.528)
0.035
≥ 100
9 (1908/2720)
Random
1.457 (1.173-1.810)
0.001
Source of controls
Population-based
9 (1484/1465)
Random
1.441 (1.039-1.997)
0.028
Hospital-based
7 (926/2204)
Fixed
1.635 (1.391-1.921)
0.000
Citation: Yu L, Wang CY, Xi B, Sun L, Wang RQ, Yan YK, Zhu LY. GST polymorphisms are associated with hepatocellular carcinoma risk in Chinese population. World J Gastroenterol 2011; 17(27): 3248-3256