Pathological and MR-DWI study of the acute hepatic injury model after stem cell transplantation

Table 1 Criteria for the acute injured liver pathological score

Score	Cellular necrosis and liver hyperplasia	Inflammatory cell infiltration in the area of the header and lobule	Injury of vascular endothelium and thrombus
0	Without	Without	Without
1	Spotty liver cell degeneration, necrosis without change of hepatic sinusoid and lobule shape	Infiltration area < 1/3 lobule or low inflammatory cell infiltration in the area of the header	Hyperemia of hepatic sinusoid or thrombus
2	Scattering severe liver cell degeneration, necrosis of whole lobule or unobvious liver cell hyperplasia	Infiltration area: 1/3-2/3 of lobule or comparatively wide-bound inflammatory cell infiltration	Injury of vascular endothelium or inflammatory cell infiltration under vascular endothelium
3	Large sheet liver cell degeneration and necrosis involving multiple lobules	Infiltration area: > 2/3 of lobule or inflammatory cells surround header	Extensive injury of vascular endothelium and thrombus

Obvious liver cell hyperplasia score: -2; Not obvious liver cell hyperplasia score: +2.

Table 2 Mean apparent diffusion coefficient values from the cell transplantation group and transplantation control group at each time point (mean ± SD) × 10^-3 mm²/s

Group	1st wk	2nd wk	4th wk
Cell transplantation group	1.07 ± 0.07	1.41 ± 0.04	1.68 ± 0.04
Transplantation control	0.69 ± 0.05	0.84 ± 0.06	0.86 ± 0.04
t	11.452	21.735	37.876
P	0.000	0.000	0.000

Table 3 Pathological scores from the cell transplantation group and transplantation control at each time point (mean ± SD)

Group	1st wk	2nd wk	4th wk
Cell transplantation group	27.14 ± 1.46	22.29 ± 2.29	19.00 ± 2.31
Transplantation control	69.29 ± 6.16	57.00 ± 1.53	51.86 ± 6.04
t	-17.619	-33.379	-13.444
P	0.000	0.000	0.000