Review of screening for pancreatic cancer in high risk individuals

doi:10.3748/wjg.v17.i19.2365

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May 21, 2011 (publication date) through Nov 3, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 21, 2011; 17(19): 2365-2371
Published online May 21, 2011. doi: 10.3748/wjg.v17.i19.2365

Table 1 Potential pancreatic cancer biomarkers under study %

Biomarker	CEACAM-1	Span-1	DUPAN-2	MIC-1	Alpha4GnT	PAM4
Sensitivity	85	81-94	48-80	90	76	77
Specificity	98	75	75-85	62	83	95

MIC-1: Macrophage inhibitory cytokine-1; CEACAM-1: Carcinoembryonic antigen-related cell adhesion molecule 1; SPan-1: Monoclonal antibody; DU-PAN 2: Pancreatic cancer associated antigen; Alpha4GnT: alpha1,4- N-acetylglucosaminyltransferase; PAM4: Anti-MUC1 monoclonal antibody.

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Table 2 Results of screening programs for pancreatic cancer in high-risk groups

Study	CAPS 1[44]	CAPS 2[43]	Washington[47,48]	FaPaCa[49]	Dutch study[50]
Yield of screening	5.30%	10%	13%	1.30%	23%¹
Yield of screening	(2/38)	(8/78)	(10/75)	(1/76)	(10/44)

¹7% diagnostic yield of pancreatic cancer and 16% diagnostic yield of premalignant IPMN lesions. CAPS: Cancer of the Pancreas Screening Study; FaPaCa: Familial Pancreatic Cancer Study Germany.

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Citation: Stoita A, Penman ID, Williams DB. Review of screening for pancreatic cancer in high risk individuals. World J Gastroenterol 2011; 17(19): 2365-2371
URL: https://www.wjgnet.com/1007-9327/full/v17/i19/2365.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i19.2365