LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese

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May 14, 2011 (publication date) through Feb 18, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright ©2011 Baishideng Publishing Group Co., Limited. All rights reserved.

World J Gastroenterol. May 14, 2011; 17(18): 2326-2331
Published online May 14, 2011. doi: 10.3748/wjg.v17.i18.2326

Table 1 Characteristics of colorectal carcinoma cases and controls n (%)

Parameters	Cases	Controls	P value
Age (mean ± SD, yr)	57.85 ± 10.05	58.10 ± 13.47	0.751
Sex
Male	259 (54.1)	254 (52.3)
Female	220 (45.9)	232 (47.7)
Total	479	486	0.574
Smoking status
Never	334 (69.7)	357 (73.5)
Former	15 (3.1)	39 (8.0)
Present	130 (27.1)	90 (18.5)
Total	479	486	0.199
Drinking status
Never	10 (2.1)	16 (3.3)
Former	280 (58.5)	207 (42.6)
Present	189 (39.5)	263 (54.1)
Total	479	486	0.248
Histological grade
High	11 (2.3)
Intermediate	296 (61.8)
Low	172 (35.9)
Location
Colon	233 (48.6)
Rectum	242 (50.5)
Colon and rectum	4 (0.8)
Stage
I	142 (29.7)
II	110 (23.0)
III	142 (29.6)
IV	85 (17.7)

Table 2 Genes, polymorphism and frequencies in colorectal carcinoma cases and controls

SNP	Genotype	Cases (n = 479)	Controls (n = 486)	Odds ratio (95% CI)	¹P value
LBP
rs1739654	GG	377 (78.7%)	360 (74.1%)
	GA	93 (19.4%)	118 (24.3%)	0.75 (0.55-1.02)	0.07
	AA	9 (1.9%)	8 (1.6%)	1.07 (0.41-2.82)	0.88
	GA+AA	102 (21.3%)	126 (25.9%)	0.77 (0.57-1.04)	0.09
rs2232596	AA	289 (60.3%)	343 (70.6%)
	GA	169 (35.3%)	133 (27.4%)	1.51 (1.15-1.99)	0.003
	GG	21 (4.4%)	10 (2%)	2.49 (1.16-5.38)	0.016
	GA+GG	190 (39.7%)	143 (29.4%)	1.58 (1.21-2.06)	0.001
rs2232618	TT	385 (80.4%)	396 (81.5%)
	CT	93 (19.4%)	88 (18.1%)	1.09 (0.79-1.50)	0.613
	CC	1 (0.2%)	2 (0.4%)	0.51 (0.05-5.70)	0.581
	CT+CC	94 (19.6%)	90 (18.5%)	1.07 (0.78-1.48)	0.662
CD14
rs77083413	GG	403 (84.1%)	400 (82.3%)
	GC	70 (14.6%)	81 (16.7%)	0.858 (0.605-1.215)	0.388
	CC	6 (1.3%)	5 (1%)	1.19 (0.36-3.93)	0.774
	GC+CC	76 (15.9%)	86 (17.7%)	0.88 (0.63-1.23)	0.447
rs4914	CC	369 (77%)	415 (85.4%)
	CG	102 (21.3%)	68 (14%)	1.69 (1.20-2.36)	0.002
	GG	8 (1.7%)	3 (0.6%)	3.00 (0.79-11.39)	0.091
	CG+GG	110 (23%)	71 (14.6%)	1.74 (1.25-2.42)	0.001
IL-6
rs13306435	TT	415 (86.6%)	420 (86.4%)
	AT	60 (12.5%)	65 (13.4%)	0.93 (0.64-1.36)	0.723
	AA	4 (0.9%)	1 (0.2%)	4.05 (0.45-36.37)	0.177
	AT+AA	64 (13.4%)	66 (13.6%)	0.98 (0.68-1.42)	0.921

¹Adjusted for age, sex, smoking and drinking status.

Table 3 Stratification analyses for rs2232596 by smoking or drinking status

Genotype frequencies (%)	Status	Cases (n = 479)	Controls (n = 486)	¹P value	Odds ratio (95% CI)
	Smoking
AA	No	131 (27.3%)	155 (31.9%)
GA	No	59 (12.3%)	55 (11.3%)	0.303	1.26 (0.81-1.95)
GG	No	10 (2.1%)	5 (1.0%)	0.292	1.86 (0.59-5.87)
GA/GG	No	69 (14.4%)	60 (12.3%)	0.190	1.32 (0.87-2.02)
AA	Yes	158 ( 33.0%)	188 ( 38.7%)
GA	Yes	100 ( 20.9%)	78 (16.0%)	0.005	1.68 (1.17-2.40)
GG	Yes	11 (2.3%)	5 (1.0%)	0.084	2.59 (0.88-7.63)
GA/GG	Yes	111 (23.2%)	85 (17.0%)	0.002	1.73 (1.22-2.46)
	Drinking
AA	No	6 (1.3%)	9 (1.9%)
GA	No	4 (0.8%)	6 (1.2%)	0.892	0.89 (0.16-5.07)
GG	No	0 (0%)	1 (0.2%)	0.998
GA/GG	No	4 (0.8%)	7 (1.4%)	0.739	0.75 (0.14-4.03)
AA	Yes	283 (59.1%)	334 (69.7%)
GA	Yes	165 (34.4%)	127 (26.1%)	0.003	1.53 (1.16-2.03)
GG	Yes	21 (4.4%)	9 (1.9%)	0.015	2.68 (1.21-5.97)
GA/GG	Yes	186 (38.8%)	136 (28.0%)	0.001	1.61 (1.23-2.11)

¹Adjusted for age, sex, and drinking or smoking status.

Table 4 Stratification analyses for rs4914 by smoking or drinking status

Genotype frequencies (%)	Status	Cases (n = 479)	Controls (n = 486)	¹P value	Odds ratio (95% CI)
	Smoking
CC	No	146 (30.5%)	191 (39.3%)
CG	No	50 (10.4%)	23 (4.7%)	0.000	2.820 (1.64-4.85)
GG	No	4 (0.8%)	1 (0.2%)	0.144	5.210 (0.57-47.55)
CG/GG	No	54 (11.2%)	24 (4.9%)	0.000	2.920 (1.72-4.96)
CC	Yes	223 (46.6%)	224 (46.1%)
CG	Yes	52 (10.9%)	45 (9.3%)	0.524	1.155 (0.74-1.80)
GG	Yes	4 (0.8%)	2 (0.4%)	0.430	1.993 (0.36-11.05)
CG/GG	Yes	56 (11.7%)	47 (9.7%)	0.429	1.190 (0.77-1.83)
	Drinking
CC	No	9 (1.9%)	10 (2.1%)
CG	No	1 (0.2%)	5 (1.0%)	0.215	0.227 (0.02-2.37)
GG	No	0 (0%)	1 (0.2%)	0.998
CG/GG	No	1 (0.2%)	6 (1.2%)	0.154	0.190 (0.02-1.88)
CC	Yes	360 (75.2%)	405 (83.3%)
CG	Yes	101 (21.1%)	63 (13.0%)	0.001	1.800 (1.28-2.55)
GG	Yes	8 (1.7%)	2 (0.4%)	0.060	4.470 (0.94-21.18)
CG/GG	Yes	109 (22.8%)	65 (13.4%)	0.000	1.890 (1.34-2.64)

¹Adjusted for age, sex and drinking or smoking status.

Table 5 Colorectal carcinoma risk with combined lipopolysaccharide binding protein rs2232596 and CD14 rs4914 SNPs

No. of riskgenotype	Cases(n = 479)	Controls(n = 486)	¹Pvalue	Odds ratio(95% CI)
“0”	235 (49.1%)	296 (60.9%)
“1”	194 (40.5%)	172 (35.4%)	0.007	1.46 (1.11-1.92)
“2”	50 (10.4%)	18 (3.7%)	0.000	3.44 (1.94-6.10)
“1+2”	244 (50.9%)	190 (39.1%)	0.000	1.66 (1.28-2.15)

¹Adjusted for age, sex, smoking and drinking status.

Citation: Chen R, Luo FK, Wang YL, Tang JL, Liu YS. LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese. World J Gastroenterol 2011; 17(18): 2326-2331
URL: https://www.wjgnet.com/1007-9327/full/v17/i18/2326.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i18.2326

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