Sunitinib for Taiwanese patients with gastrointestinal stromal tumor after imatinib treatment failure or intolerance

Table 1 Demographic and genetic data of 23 Taiwanese gastrointestinal stromal tumor patients with imatinib failure or intolerance treated with sunitinib n (%)

	Sunitinib (n = 23)
Age (median/range, yr)	59.0/24-83
Gender (male:female)	16:7
Location
Stomach	8 (26.6)
Duodenum	1 (12.5)
Jejunum	5 (23.4)
Ileum	5 (14.1)
Mesentery	1 (18.8)
Rectum	3 (4.7)
Tumor recurrence
Liver	15
Peritoneum	6
Local recurrence	2
Genetic spectrum	21 (84.4)
Exon 11	12
Deletion mutation
Deletion and insertion mutation
Missense mutation
Exon 9 (insertion mutation)	6
Exon 13	1
No mutation (wild type)	1
PDGFRA (exon 18)	1
Median duration of sunitinib use (mo)	6

PDGFRA: Platelet derived growth factor α.

Table 2 Antitumor response of 23 Taiwanese with advanced gastrointestinal stromal tumor treated with sunitinib

	n (%)	Sunitinib duration (median, mo)	TTR/TTP (median, mo)	OS (median, mo)
CR	2 (8.7)	9.85	3.73/NA	NA
PR	4 (17.4)	12.3	3.67/12.71	NA
SD	9 (39.1)	11.9	1.87/13.53	14.03
PD	8 (34.8)	3.63	2.37	NA

CR: Complete response; PR: Partial response; SD: Stationary disease; PD: Progression of disease; TTR: Time to response; TTP: Time to progression; OS: Overall survival.

Table 3 Correlation between antitumor response and mutation status of 21 Taiwanese with advanced gastrointestinal stromal tumor treated with sunitinib

	CR	PR	SD	PD	P	CR + PR + SD	PD	P
Exon 9 (n = 6)	0	1	2	3	0.6101	3	3	0.3441
Exon 11 (n = 12)	2	2	5	3		9	3
Exon 13 (n = 1)	0	0	0	1
No mutation (n = 1)	0	0	1	1
PDGFRA (n = 1)	0	1	0	0

¹Exon 9 vs exon 11. CR: Complete response; PR: Partial response; SD: Stationary disease; PD: Progression of disease; PDGFRA: Platelet derived growth factor α.

Table 4 Adverse events and selected laboratory abnormalities

Variable	Sunitinib (n = 23)
	Grade 1	Grade 2	Grade 3	Grade 4
Adverse event
Anorexia	5	1	0	0
Diarrhea	6	8	0	0
Constipation	1	2	0	0
Fatigue	2	2	0	0
Nausea	0	0	0	0
Mucositis/stomatitis	4	0	0	0
Vomiting	1	0	0	0
Hypertension	4	4	1	0
Hand-foot syndrome	1	2	6	0
Rash	1	4	0	0
Skin discoloration	5	0	0	0
Fever	2	0	1	0
Laboratory abnormalities
Leukopenia	4	6	1	0
Neutropenia	2	4	3	0
Febrile neutropenia	0	0	1	0
Anemia	8	6	4	0
Elevated creatinine	4	4	0	0
Thrombocytopenia	6	7	0	0
AST	7	1	0	0
ALT	4	0	0	0
Total bilirubin	3	1	1	0
GFR	3	2	0	0
Hypothyroidism	0	0	0	0

AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GFR: Glomerular filtration rate.