Microscopic colitis as a missed cause of chronic diarrhea

Table 1 Microscopic colitis cases identified by IHC using CD3

	No. of cases	1P value
Cases marked as normal, chronic inflammation or melanosis coli	241
IELs > 20	20	< 0.001
Known case of LC	1	0.158
Missed LC	5	< 0.001
Collagenous colitis	2	0.078
Microscopic colitis (Total No. of cases)	8	< 0.001

¹P value for comparing whether the proportion was different from 0. LC: Lymphocytic colitis.

Table 2 Clinicopathological features and follow-up data in patients with > 20 intra-epithelial lymphocytes

Age	Sex	IEL count	Presenting symptom	Original biopsy diagnosis	Follow-up period for 2 yr
32	F	22	Chronic diarrhea	Normal	Lymphocytic colitis12
32	F	27	Chronic diarrhea	Normal	Lymphocytic colitis2
55	F	27	Constipation	Normal	Resolve
65	M	26	Abdominal pain	Normal	Myelodysplastic syndrome
22	F	31	Constipation	Normal	Lost to follow up
35	M	38	Chronic diarrhea	Normal	Lymphocytic colitis1
42	F	30	Constipation	Normal	Lost to follow up
59	F	28	Abdominal pain	Normal	Resolve
59	F	40	Chronic diarrhea	Normal	Multiple liver lesions
56	M	31	Chronic diarrhea	Normal	Ulcerative colitis
79	F	20	Abdominal pain	Melanosis coli	Diverticulitis
19	F	28	Abdominal pain	Normal	Behcet’s disease
24	F	24	Chronic diarrhea	Normal	Lymphocytic colitis2
51	M	48	Chronic diarrhea	Normal	Metastatic renal cell carcinoma
56	F	30	Chronic diarrhea	Normal	Lymphocytic colitis2
34	F	30	Abdominal pain	Normal	Resolved
33	F	30	Chronic diarrhea	Lymphocytic colitis	Lymphocytic colitis3
71	M	20	Loss of weight	Normal	Diverticulitis
59	F	25	Abdominal pain	Normal	Resolve
35	F	35	Abdominal pain	Melanosis coli	Pancreatitis

¹Lost to follow-up;

²On review diagnosis changed from irritable bowel syndrome to lymphocytic colitis;

³Known patient included in the study. IEL: Intra-epithelial lymphocyte.

Table 3 Clinicopathological features and follow-up data on patients with chronic diarrhea and 10-19 Intra-epithelial lymphocytes

Age	Sex	IEL count	Original diagnosis	Comorbid disease	Follow-up period for 2 yr
					Diagnosis	Diarrhea
54	F	10	Chronic inflammation	Diabetic hypertension	Lactose intolerant	Persistent
70	F	12	Melanosis coli	Diabetic	Autonomic neuropathy	Persistent
22	M	13	Chronic inflammation		Lost to FU	Lost to FU
64	M	15	Melanosis coli	Diabetic, asthmatic	Autonomic neuropathy	Persistent
59	F	16	Melanosis coli	Schistosomiasis contact	Irritable bowel syndrome	Persistent
64	F	18	Normal	Diabetic, asthmatic, previous sigmoidectomy for benign stricture	Hypothyroid	Persistent

IEL: Intra-epithelial lymphocyte; FU: Follow-up.