Salvianolate inhibits cytokine gene expression in small intestine of cirrhotic rats

doi:10.3748/wjg.v17.i14.1903

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Apr 14, 2011 (publication date) through Nov 26, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 14, 2011; 17(14): 1903-1909
Published online Apr 14, 2011. doi: 10.3748/wjg.v17.i14.1903

Table 1 Forward and reverse primers used in quantitative real-time polymerase chain reaction

Gene	Primer sequence (5’-3’)	Annealing temperature (°C)	Product size (bp)
β-actin	5’-ACTGCCGCATCCTCTTCCTC-3’ 5’-ACTCCTGCTTGCTGATCCACAT-3’	55	598
Rat TNF-α	5’-GGCAGGTCTACTTTGGAGTCATTGC-3’	58	318
Rat TNF-α	5’-ACATTCGGGGATCCAGTGAGCTCCG-3’	58	318
Rat IL-6	5’-GGATACCACCCACAACAG-3’ 5’-GGTCCTTAGCCACTCCTT-3’	58	451

TNF: Tumor necrosis factor; IL: Interleukin.

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Table 2 Mortality of rats in different groups

Group	n	Mortality values
A	10	0 (0/10)^a
B	14	37.5% (6/14)
C	14	21.42% (3/14)
D	14	21.42% (3/14)
E	13	0 (0/13)^a

^aP < 0.05 vs non treatment group. A: Normal control group; B: Non treatment group; C: Low-dose salvianolate treatment group; D: Medium-dose salvianolate treatment group; E: High-dose salvianolate treatment group.

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Table 3 Distribution of endotoxin levels in serum of different groups

Group	n	Dose (mg/kg)	Levels of endotoxin (pg/L)
Group	n	Dose (mg/kg)	0-1	1-10	10-20	> 20	Mean rank
A	10	-	10	0	0	0	15.35^b
B	14	-	2	2	3	7	55.71
C	14	12	8	4	2	0	47.54^a
D	14	24	12	1	1	0	29.14^b
E	13	48	12	1	0	0	14.57^b

^aP < 0.05,

^bP < 0.01 vs non treatment group. A: normal control group; B: non treatment group; C: low-dose salvianolate treatment group; D: medium-dose salvianolate treatment group; E: high-dose salvianolate treatment group.

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Citation: Yang DH, Ye ZY, Jin B, He XJ, Zhang Q, Zhou WM, Xu WJ, Lu HX. Salvianolate inhibits cytokine gene expression in small intestine of cirrhotic rats. World J Gastroenterol 2011; 17(14): 1903-1909
URL: https://www.wjgnet.com/1007-9327/full/v17/i14/1903.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i14.1903