Association between polymorphism rs6983267 and gastric cancer risk in Chinese population

Table 1 Characteristics of cases and control

Variables	Gastric cancer n (%)	Control n (%)	P value2
Overall	212	377
Sex			0.063
Male	152 (71.7)	242 (64.2)
Female	60 (28.3)	135 (35.8)
Age			0.670
Mean ± SD (yr)	62.47 ± 11.6	62.89 ± 11.3
Histological types
Intestinal	155 (73.1)
Diffuse	44 (20.8)
Mixed	13 (6.1)
Tumor location1
Cardia	74 (38.5)
Noncardia	118 (61.5)

¹The number of subjects in cases for tumor location (n = 192) was less than the total number (n = 212) because some information was not obtained;

²Two-sided χ² test for the frequency distribution of variants between gastric cancer cases and controls.

Table 2 Association between variation in single nucleotide polymorphisms rs6983267 and rs708482 and risk of gastric cancer

Genotype	Control n (%)	Cases n (%)	P value
rs6983267
GT/TT	268 (72.8)	166 (83.0)	0.007
TT	72 (19.6)	32 (16.0)	0.369
GT	196 (53.3)	134 (67.0)	0.002
GG	100 (27.2)	34 (17.0)
rs7008482
GT/GG	224 (61.0)	142 (67.0)	0.138
GG	52 (14.2)	38 (17.9)	0.108
GT	172 (46.9)	104 (49.1)	0.250
TT	143 (39.0)	70 (33.0)

Table 3 Association between rs6983267 and rs7008482 polymorphism and clinicopathological features of gastric cancer

	rs6983267							rs7008482
	GG	GT			TT			TT	GT			GG
	HC/GC	HC/GC	OR (95% CI)	P value	HC/GC	OR (95% CI)	P value	HC/GC	HC/GC	OR (95% CI)	P value	HC/GC	OR (95% CI)	P value
Age (yr)
≤ 60	46/11	76/59	3.21 (1.52-6.77)	0.002	29/13	1.86 (0.73-4.72)	0.191	66/30	71/46	1.42 (0.80-2.51)	0.230	15/11	1.61 (0.66-3.92)	0.295
> 60	54/23	120/75	1.54 (0.87-2.74)	0.137	43/19	1.05 (0.50-2.16)	0.901	77/40	101/58	1.15 (0.69-1.90)	0.592	37/27	1.44 (0.77-2.70)	0.258
Sex
Male	60/26	125/94	1.77 (1.04-3.02)	0.036	48/23	1.10 (0.56-2.17)	0.783	98/46	107/77	1.52 (0.96-2.41)	0.072	32/29	1.88 (1.01-3.47)	0.045
Female	40/8	71/40	3.68 (1.49-9.06)	0.005	24/9	2.22 (0.73-6.74)	0.160	45/24	65/27	0.83 (0.42-1.65)	0.599	20/9	0.98 (0.38-2.54)	0.967
Histological types
Intestinal	100/26	196/98	1.92 (1.17-3.15)	0.010	72/23	1.20 (0.63-2.28)	0.571	143/52	172/73	1.17 (0.77-1.78)	0.047	52/30	1.56 (0.89-2.72)	0.118
Diffuse	100/7	196/25	1.93 (0.80-4.66)	0.144	72/8	1.74 (0.60-5.09)	0.309	143/15	172/23	1.36 (0.68-2.71)	0.390	52/6	1.26 (0.46-3.47)	0.651
Mixed	100/1	196/11	5.56 (0.71-44.52)	0.103	72/1	1.37 (0.08-21.06)	0.827	143/3	172/8	2.29 (0.63-9.43)	0.228	52/2	1.95 (0.34-13.47)	0.474
Location
Cardia	100/16	196/40	1.26 (0.67-2.38)	0.469	72/14	1.18 (0.54-2.58)	0.681	143/25	172/35	1.18 (0.67-2.07)	0.574	52/14	1.52 (0.73-3.18)	0.263
Noncardia	100/16	196/82	2.64 (1.46-4.75)	0.001	72/12	1.06 (0.47-2.38)	0.888	14/39	172/59	1.28 (0.81-2.04)	0.295	52/20	1.47 (0.78-2.77)	0.228

Multivariate unconditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CIs) for the association between genotypes and gastric cancer, adjusting for age and gender. HC: Health control; GC: Gastric cancer.

Table 4 Stratified analysis of rs6983267 genotypes and gastric cancer

	Control n (%)	Intestinal case		Diffuse case
		n (%)	OR (95% CI)	n (%)	OR (95% CI)
Cardia
TT	72 (19.6)	12 (22.2)	1.243 (0.53-2.90)	1 (8.3)	0.44 (0.04-4.31)
GT	196 (53.3)	29 (53.7)	1.131 (0.56-2.28)	8 (66.7)	1.36 (0.35-5.28)
GG	100 (27.1)	13 (24.1)		3 (25)
Noncardia
TT	72 (19.6)	8 (9.6)	0.99 (0.38-2.59)	4 (16.7)	1.91 (0.44-8.25)
GT	196 (53.3)	64 (77.1)	2.95 (1.49-5.86)	16 (66.6)	2.56 (0.80-8.17)
GG	100 (27.1)	11 (13.3)		4 (16.7)