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©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 7, 2011; 17(13): 1710-1717
Published online Apr 7, 2011. doi: 10.3748/wjg.v17.i13.1710
Published online Apr 7, 2011. doi: 10.3748/wjg.v17.i13.1710
Table 1 Clinicopathological characteristics of all patients
Variables | Cases | Training dataset(n = 39) | Validation dataset(n = 33) | P |
Sex | ||||
Male | 53 | 28 | 25 | 0.79 |
Female | 19 | 11 | 8 | |
Age (yr) | ||||
mean ± SE | 72 | 60.9 ± 1.5 | 61.6 ± 1.3 | 0.74 |
Depth of wall invasion | ||||
T2 | 4 | 3 | 1 | 0.121 |
T3 | 56 | 32 | 24 | |
T4 | 12 | 4 | 8 | |
Differentiation | ||||
Well | 7 | 5 | 2 | 0.181 |
Moderate | 31 | 14 | 17 | |
Poor | 27 | 18 | 9 | |
Undifferentiated2 | 7 | |||
Lymph node metastasis | ||||
Negative | 16 | 10 | 6 | 0.57 |
Positive | 56 | 29 | 27 | |
Distance metastasis | ||||
M0 | 66 | 38 | 28 | 0.09 |
M1 | 6 | 1 | 5 | |
TNM stages | ||||
I + II | 17 | 12 | 5 | 0.301 |
III | 33 | 18 | 15 | |
IV | 22 | 9 | 13 |
Table 2 The ten-gene prognostic marker correlated to patients’ survival
Symbol | Cox score | Description |
RPS19 | 2.93 | Ribosomal protein S19 |
RPS8 | 2.90 | Ribosomal protein S8 |
RPS2P12 | 2.62 | Predicted ribosomal protein S2 |
RPS12 | 2.59 | Ribosomal protein S12 |
RPS15P4 | 2.57 | Predicted 40S ribosomal protein S15 |
RPLP2 | 2.51 | Ribosomal protein, large, P2 |
EIF3S6 | 2.61 | Eukaryotic translation initiation factor 3 |
GLTSCR2 | 2.67 | Tumor suppressor candidate region gene 2 |
TMSB10 | 2.47 | Thymosin, beta 10 |
SEC61G | -2.98 | Sec61 gamma subunit |
Table 3 Association between different prognosis groups identified by the ten-gene marker and the clinicopathological characteristics
Variables | Cases | Prolonged survival(n = 12) | Poor survival(n = 21) | P |
Sex | ||||
Male | 14 | 9 | 5 | 0.070 |
Female | 18 | 3 | 15 | |
Age (yr) | ||||
mean ± SE | 33 | 58.1 ± 2.2 | 63.5 ± 1.5 | 0.040 |
Depth of wall invasion | ||||
T2 | 1 | 1 | 0 | 0.120 |
T3 | 24 | 11 | 13 | |
T4 | 8 | 0 | 8 | |
Differentiation | ||||
Well | 2 | 1 | 1 | 0.490 |
Moderate | 17 | 8 | 9 | |
Poor | 9 | 2 | 7 | |
Undifferentiated1 | 5 | |||
Lymph Node Metastasis | ||||
Negative | 6 | 4 | 2 | 0.160 |
Positive | 27 | 8 | 19 | |
Distance metastasis | ||||
M0 | 28 | 12 | 16 | 0.080 |
M1 | 5 | 0 | 5 | |
TNM stages | ||||
II | 5 | 5 | 0 | 0.002 |
III | 15 | 5 | 10 | |
IV | 13 | 2 | 11 |
Table 4 Multivariate Cox regression for overall survival in validation dataset
Variables | P | HR | CI (95%) |
Depth of wall invasion | 0.370 | 1.66 | 0.55-4.90 |
Differentiation | 0.240 | 4.93 | 0.15-1.58 |
Lymph node metastasis | 0.780 | 0.77 | 0.13-4.53 |
Distance metastasis | 0.120 | 0.32 | 0.08-1.35 |
Ten-gene prognostic marker | 0.007 | 0.13 | 0.29-0.56 |
- Citation: Zhang YZ, Zhang LH, Gao Y, Li CH, Jia SQ, Liu N, Cheng F, Niu DY, Cho WC, Ji JF, Zeng CQ. Discovery and validation of prognostic markers in gastric cancer by genome-wide expression profiling. World J Gastroenterol 2011; 17(13): 1710-1717
- URL: https://www.wjgnet.com/1007-9327/full/v17/i13/1710.htm
- DOI: https://dx.doi.org/10.3748/wjg.v17.i13.1710