Reactivation of hepatitis B virus infection after cytotoxic chemotherapy or immunosuppressive therapy

Table 1 Onco-hematological diseases and reactivation of hepatitis B

Hematologic diseases	Hematological tumors
Non-hodgkin lymphoma	Breast cancer
Hodgkin lymphoma	Lung cancer
Chronic lymphocytic leukemia	Hepatocellular carcinoma
Chronic myeloid leukemia	Nasopharyngeal cancer
Acute myeloid leukemia	Other cancers
Acute lymphoblastic leukemia
Multiple myeloma
Waldenstrom macroglobulinemia
Plasmacytoma
Aplastic anemia
Myelodysplastic syndrome
Bone marrow transplantation

Table 2 Chemotherapy and reactivation of hepatitis B

Classes	Drugs
Alkylating agents	Cyclophosphamide, chlorambucil, cisplatin
Alkaloids	Vincristine, vinblastine
Antibiotics	Doxorubicin, epirubicin, daunorubicin, bleomycin, mitomycin C, actinomycin D
Antimetabolites	Cytarabine, fluorouracil, gemcitabine, mercaptopurine, methotrexate, thioguanine
Monoclonal antibodies	Rituximab (anti-CD20), alemtuzumab (anti-CD52)
Corticosteroids	Dexamethasone, methylprednisolone, prednisone
Others	Folinic acid, colaspase, docetaxel, etoposide, fludarabine, interferon, procarbazine

Table 3 Infliximab treatment and cases of hepatitis B reactivation

17 reports (2003-2009) (n = 21)	n
Michel et al[26], 2003	1
Ostuni et al[27], 2003	1
Oniankitan et al[28], 2004	1
Esteve et al[29], 2004	3
Wendling et al[30], 2005	1
Ueno et al[31], 2005	1
Anelli et al[32], 2005	1
Millonig et al[33], 2006	1
Roux et al[34], 2006	1
Calabrese et al[35], 2006	1
Colbert et al[36], 2007	1
Madonia et al[37], 2007	1
Sakellariou et al[38], 2007	2
Ojiro et al[39], 2008	1
Chung et al[40], 2009	1
Conde-Taboada et al[41], 2009	1
Wendling et al[42], 2009	1