Increased liver stiffness in alcoholic liver disease: Differentiating fibrosis from steatohepatitis

Table 1 Patients’ characteristics of the learning cohort and validation cohort

Parameter	Learning cohort (n = 50)		Validation cohort (n = 101)
	mean	SD	mean	SD
Male	37		73
Female	13		28
Age (yr)	55.8	10.8	53.2	10.6
BMI (kg/m²)	26.0	4.4	25.4	4.2
GOT (U/L)	135.2	99.9	95.0	76.0
GPT (U/L)	104.6	173.4	90.2	133.7
GGT (U/L)	591.1	828.0	568.6	762.8
AP (U/L)	129.8	102.7	131.9	110.4
Bilirubin (mg/dL)	2.1	3.3	2.0	3.9
Albumin (g/dL)	4.0	0.6	4.0	0.7
Protein (g/dL)	7.0	0.7	7.0	0.8
Quick (%)	98.5	19.5	95.3	20.8
INR	1.0	0.2	1.0	0.2
Urea	32.5	42.5	27.1	31.8
Creatinine (mg/dL)	0.9	0.5	0.8	0.4
PTT (s)	34.9	7.6	35.1	7.9
Hb (g/dL)	13.7	1.9	13.5	2.0
Hk (%)	39.9	5.3	39.7	5.6
Erythrocytes (/pL)	4.1	0.6	4.0	0.6
Leukocytes (/nL)	7.0	2.0	7.3	2.9
Thrombocytes (/nL)	202.5	99.2	204.5	112.5
Glucose (mg/dL)	100.1	20.7	97.2	18.9
HbA1C (%)	5.7	1.7	5.5	1.3
Triglycerides (mg/dL)	222.4	259.5	204.1	208.8
Cholesterin (mg/dL)	217.5	51.8	212.5	63.6
Ferritin (ng/mL)	636.3	580.7	671.7	589.4
Transferrin (g/L)	2.2	0.4	2.1	0.5
Iron (μg/dL)	109.0	51.9	107.1	59.6
CRP (mg/dL)	2.2	3.8	2.3	3.1
Alcohol (g/d)	144.1	106.1	146.8	100.8
LS (kPa)	20.1	24.3	20.4	22.4

GOT: Glutamic oxaloacetic transaminase; GGT: γ glutamyl transferase; GPT: Glutamic pyruvic transaminase; AP: Alkaline phosphatase; INR: International normalized ratio; PTT: Prothrombin time; Hb: Hemoglobin; Hk: Hematocrit; HbA1C: Glycosylated Hb; CRP: C-reactive protein; LS: Liver stiffness; BMI: Body mass index.

Table 2 Excluding patients with elevated GOT levels indicating steatohepatitis improves the diagnostic value (AUROC, sensitivity and specificity) of FibroScan for the diagnosis of F3/F4 fibrosis

	Area under the curve (AUROC)	Std. error	Cut-off value (kPa)	Sensitivity	Specificity	Number of includedpatients
F4	0.921	0.03	11.5	1.00	0.77	101
			12.51	0.961	0.801	1011
F4 without GOT > 100 U/L	0.944	0.02	11.5	1.00	0.84	86
			12.51	0.951	0.901	861
F4 without GOT > 50 U/L	0.945	0.03	10.4	1.00	0.87	66
			12.51	0.921	0.911	661
F3/4	0.914	0.03	8.0	0.91	0.75	101
F3/4 without GOT > 100 U/L	0.922	0.03	8.0	0.87	0.87	80
F3/4 without GOT > 50 U/L	0.946	0.03	8.0	1.00	0.84	67

¹Represent commonly used cut-off values (12.5 and 8.0 kPa) for comparison with other studies. Additional cut-off values with 100% sensitivity and different cut-off values for F4 fibrosis are specific to this study.