Preparation, physicochemical characterization and cytotoxicity in vitro of gemcitabine-loaded PEG-PDLLA nanovesicles

Table 1 Drug incorporation efficiency of Gemcitabine-load nanovesicles (%)

Sample	1	2	3	mean ± SD
Drug content	4.23	3.99	4.19	4.14 ± 0.13
Drug encapsulation efficiency	21.34	19.54	20.75	20.54 ± 0.92

Table 2 The inhibitory effect of Gemcitabine-loaded nanovesicles and free gemcitabine on human SW1990 pancreatic cancer cells

Drug concentration (mol/L)	Gemcitabine-loaded nanovesicles	Free gemcitabine	P value
	Cell inhibitory rate (%)	Cell inhibitory rate (%)
10-7	18.3 ± 1.6	21.7 ± 2.5	0.480
10-6	46.2 ± 2.7	49.5 ± 4.1	0.619
10-5	82.3 ± 5.4	78.8 ± 4.2	0.592
10-4	93.2 ± 5.3	95.2 ± 3.7	0.552