Therapy and prognostic features of primary clear cell carcinoma of the liver

Table 1 Univariate analysis of clinicopathological variables associated with the prognosis of PCCCL

Parameters	Cases	Median survival time (95% CI) (mo)	χ2-value	P-value
AFP range (ng/mL)
≥ 200	26	31 (27.302-34.698)	1.413	0.285
< 200	38	49 (42.211-55.789)
Liver cirrhosis (+)
Positive	56	31 (28.013-33.987)	6.032	0.014
Negative	8	43 (38.303-47.697)
Capsule formation
Positive	46	61 (53.106-68.894)	10.241	0.001
Negative	18	19 (16.690-21.310)
Number of nodules
Single	44	61 (53.014-68.986)	4.028	0.045
Multiple	20	11 (9.675-12.325)
Child-Pugh classification
A	35	60 (51.023-68.977)	11.330	0.003
B or C	21	25 (23.302-28.698)
Vascular invasion
Positive	30	27 (23.346-30.654)	11.755	0.001
Negative	34	41 (35.437-46.563)
lymph node metastases
Positive	12	31 (26.012-35.988)	0.023	0.880
Negative	52	40 (37.342-44.658)
TNM staging
I, II	12	43 (39.211-46.789)	16.192	0.001
III, IV	52	27 (25.371-28.629)
Proportion of clear cells
≥ 70%	36	41 (35.535-46.465)	7.342	0.006
< 70%	28	19 (16.964-21.036)

PCCCL: Primary clear cell carcinoma of the liver.

Table 2 Multivariate analysis of clinicopathological variables associated with the prognosis of PCCCL

Parameters	Regression coefficient	Wald value	P value	RR (95% CI)
Proportion of clear cells	1.409	6.898	0.009	4.090 (1.430-11.702)
Capsule formation	-1.364	5.172	0.023	0.256 (0.079-0.828)
Vascular invasion	1.686	9.923	0.002	5.395 (1.890-15.398)
Child-Pugh classification	1.917	4.119	0.042	6.798 (3.253-17.334)