Brief Article
Copyright ©2010 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 21, 2010; 16(43): 5510-5517
Published online Nov 21, 2010. doi: 10.3748/wjg.v16.i43.5510
Table 1 Characteristics and quality assessment of 10 included case-control studies
StudyYrCountryEthnicityPolymorphisms of COX-2No. of participantsQuality scores
Pereira et al[25]2006PortugalCaucasians-765G>C73a/210c33
Liu et al[27]2006ChinaAsians-765G>C, -1195G>A, Gly587Arg(G>A)248a/427c33
Zhang et al[28]2006ChinaAsians-765G>C, -1195G>A, -1290A>G323a/646c28
Jiang et al[29]2007ChinaAsians-1195G>A, 8473T>C254a/304c36
Hou et al[26]2007PolandCaucasians-765G>C, IVS5-275T>G, IVS7+111T>C, V102V(G>C), *429T>C, *2430C>T464a/480c33
Canzian et al[32]2008VenezuelaHispanicsIVS5-275T>G, V102V, *429T>C1169a/1863b39
Zhu et al[30]2008ChinaAsians-765G>C, 587codonG>A140a/125c37
Saxena et al[33]2008IndiaIndians-765G>C62a/241d34
Sitarz et al[18]2008NetherlandsDutch-765G>C241a/100c31
Tang et al[31]2009ChinaAsians-765G>C100a/105c29
Table 2 The genotype distribution of COX-2 polymorphisms and the variant allele frequency n (%)
PolymorphismStudyCases
Controls
Variant allele frequencyOR (95% CI)
nVariant allele carriersnVariant allele carriers
-765G>CPereira et al[25]7337 (51)21080 (38)0.221.67 (0.98-2.86)
Liu et al[27]38842 (11)42743 (10)0.051.08 (0.69-1.70)
Zhang et al[28]32335 (11)64626 (4)0.022.90 (1.71-4.91)
Hou et al[26]29080 (28)409121 (30)0.160.91 (0.65-1.27)
Zhu et al[30]14038 (27)12520 (26)0.061.96 (1.07-3.59)
Saxena et al[33]6248 (77)24170 (29)0.168.38 (4.34-16.16)
Sitarz et al[18]24165 (27)10041 (41)0.250.53 (0.33-0.87)
Tang et al[31]10045 (45)10529 (28)0.062.14 (1.20-3.84)
Pooled OR = 1.71 (1.01-2.90)
-1195G/ALiu et al[27]389316 (81)427322 (75)0.501.41 (1.01-1.98)
Zhang et al[28]323291 (90)646510 (79)0.522.43 (1.61-3.66)
Jiang et al[29]254206 (81)304242 (80)0.261.17 (0.77-1.77)
Pooled OR = 1.58 (1.05-2.38)
Gly587Arg (G>A)Liu et al[27]38618 (15)40723 (6)0.030.82 (0.43-1.54)
-1290A>GZhang et al[28]32340 (12)64654 (8)0.041.55 (1.01-2.39)
8473T/CJiang et al[29]25495 (37)304105 (34)0.111.13 (0.80-1.60)
IVS5-275T>GHou et al[26]31193 (30)421123 (29)0.161.03 (0.75-1.42)
Canzian et al[32]10836 (33)1003392 (39)0.220.78 (0.51-1.19)
Pooled OR = 0.93 (0.71-1.21)
IVS7+111T>CHou et al[26]29978 (26)421114 (27)0.150.95 (0.68-1.33)
V102VHou et al[26]30272 (24)410125 (30)0.160.71 (0.51-1.00)
Canzian et al[32]11532 (28)1053214 (20)0.111.51 (0.98-2.3)
Pooled OR = 1.03 (0.49-2.14)
*429T>CHou et al[26]304167 (55)165 (40)251 (60)0.360.80 (0.59-1.08)
Canzian et al[32]53 (49)56 (51)398 (38)644 (62)0.380.65 (0.44-0.97)
Pooled OR = 0.74 (0.59-0.95)
*2430C >THou et al[26]289 (94)19 (6)399 (98)10 (2)0.012.62 (1.20-5.73)
587codonG>AZhu et al[30]121 (86)19 (14)112 (90)13 (10)0.061.35 (0.64-2.87)