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©2010 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 21, 2010; 16(43): 5510-5517
Published online Nov 21, 2010. doi: 10.3748/wjg.v16.i43.5510
Published online Nov 21, 2010. doi: 10.3748/wjg.v16.i43.5510
Study | Yr | Country | Ethnicity | Polymorphisms of COX-2 | No. of participants | Quality scores |
Pereira et al[25] | 2006 | Portugal | Caucasians | -765G>C | 73a/210c | 33 |
Liu et al[27] | 2006 | China | Asians | -765G>C, -1195G>A, Gly587Arg(G>A) | 248a/427c | 33 |
Zhang et al[28] | 2006 | China | Asians | -765G>C, -1195G>A, -1290A>G | 323a/646c | 28 |
Jiang et al[29] | 2007 | China | Asians | -1195G>A, 8473T>C | 254a/304c | 36 |
Hou et al[26] | 2007 | Poland | Caucasians | -765G>C, IVS5-275T>G, IVS7+111T>C, V102V(G>C), *429T>C, *2430C>T | 464a/480c | 33 |
Canzian et al[32] | 2008 | Venezuela | Hispanics | IVS5-275T>G, V102V, *429T>C | 1169a/1863b | 39 |
Zhu et al[30] | 2008 | China | Asians | -765G>C, 587codonG>A | 140a/125c | 37 |
Saxena et al[33] | 2008 | India | Indians | -765G>C | 62a/241d | 34 |
Sitarz et al[18] | 2008 | Netherlands | Dutch | -765G>C | 241a/100c | 31 |
Tang et al[31] | 2009 | China | Asians | -765G>C | 100a/105c | 29 |
Polymorphism | Study | Cases | Controls | Variant allele frequency | OR (95% CI) | ||
n | Variant allele carriers | n | Variant allele carriers | ||||
-765G>C | Pereira et al[25] | 73 | 37 (51) | 210 | 80 (38) | 0.22 | 1.67 (0.98-2.86) |
Liu et al[27] | 388 | 42 (11) | 427 | 43 (10) | 0.05 | 1.08 (0.69-1.70) | |
Zhang et al[28] | 323 | 35 (11) | 646 | 26 (4) | 0.02 | 2.90 (1.71-4.91) | |
Hou et al[26] | 290 | 80 (28) | 409 | 121 (30) | 0.16 | 0.91 (0.65-1.27) | |
Zhu et al[30] | 140 | 38 (27) | 125 | 20 (26) | 0.06 | 1.96 (1.07-3.59) | |
Saxena et al[33] | 62 | 48 (77) | 241 | 70 (29) | 0.16 | 8.38 (4.34-16.16) | |
Sitarz et al[18] | 241 | 65 (27) | 100 | 41 (41) | 0.25 | 0.53 (0.33-0.87) | |
Tang et al[31] | 100 | 45 (45) | 105 | 29 (28) | 0.06 | 2.14 (1.20-3.84) | |
Pooled OR = 1.71 (1.01-2.90) | |||||||
-1195G/A | Liu et al[27] | 389 | 316 (81) | 427 | 322 (75) | 0.50 | 1.41 (1.01-1.98) |
Zhang et al[28] | 323 | 291 (90) | 646 | 510 (79) | 0.52 | 2.43 (1.61-3.66) | |
Jiang et al[29] | 254 | 206 (81) | 304 | 242 (80) | 0.26 | 1.17 (0.77-1.77) | |
Pooled OR = 1.58 (1.05-2.38) | |||||||
Gly587Arg (G>A) | Liu et al[27] | 386 | 18 (15) | 407 | 23 (6) | 0.03 | 0.82 (0.43-1.54) |
-1290A>G | Zhang et al[28] | 323 | 40 (12) | 646 | 54 (8) | 0.04 | 1.55 (1.01-2.39) |
8473T/C | Jiang et al[29] | 254 | 95 (37) | 304 | 105 (34) | 0.11 | 1.13 (0.80-1.60) |
IVS5-275T>G | Hou et al[26] | 311 | 93 (30) | 421 | 123 (29) | 0.16 | 1.03 (0.75-1.42) |
Canzian et al[32] | 108 | 36 (33) | 1003 | 392 (39) | 0.22 | 0.78 (0.51-1.19) | |
Pooled OR = 0.93 (0.71-1.21) | |||||||
IVS7+111T>C | Hou et al[26] | 299 | 78 (26) | 421 | 114 (27) | 0.15 | 0.95 (0.68-1.33) |
V102V | Hou et al[26] | 302 | 72 (24) | 410 | 125 (30) | 0.16 | 0.71 (0.51-1.00) |
Canzian et al[32] | 115 | 32 (28) | 1053 | 214 (20) | 0.11 | 1.51 (0.98-2.3) | |
Pooled OR = 1.03 (0.49-2.14) | |||||||
*429T>C | Hou et al[26] | 304 | 167 (55) | 165 (40) | 251 (60) | 0.36 | 0.80 (0.59-1.08) |
Canzian et al[32] | 53 (49) | 56 (51) | 398 (38) | 644 (62) | 0.38 | 0.65 (0.44-0.97) | |
Pooled OR = 0.74 (0.59-0.95) | |||||||
*2430C >T | Hou et al[26] | 289 (94) | 19 (6) | 399 (98) | 10 (2) | 0.01 | 2.62 (1.20-5.73) |
587codonG>A | Zhu et al[30] | 121 (86) | 19 (14) | 112 (90) | 13 (10) | 0.06 | 1.35 (0.64-2.87) |
- Citation: Liu JL, Liang Y, Wang ZN, Zhou X, Xing LL. Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: A meta-analysis. World J Gastroenterol 2010; 16(43): 5510-5517
- URL: https://www.wjgnet.com/1007-9327/full/v16/i43/5510.htm
- DOI: https://dx.doi.org/10.3748/wjg.v16.i43.5510