Incidence of congenital hemolytic anemias in young cholelithiasis patients

Table 1 Mean values of blood parameters for suspected patients and patients with normal hematologic findings

Variables	Normal		Suspected		P
	No. patients	mean ± SD	No. patients	mean ± SD
Age (yr)	40	28.8 ± 3.9	12	27.2 ± 5.0	0.356
Total cholesterol (mg/dL)	39	181.5 ± 36.6	11	184.2 ± 34.1	0.886
HDL (mg/dL)	39	46.8 ± 13.9	11	47.0 ± 12.5	0.905
LDL (mg/dL)	39	112.6 ± 33.2	11	117.9 ± 20.82	0.546
Triglyceride (mg/dL)	38	131.2 ± 87.3	10	135.8 ± 57.2	0.916
Total bilirubin (mg/dL)	40	0.62 ± 0.35	10	0.50 ± 0.22	0.214
Indirect bilirubin (mg/dL)	40	0.42 ± 0.26	10	0.37 ± 0.18	0.505
LDH (U/L)	39	135.5 ± 35.0	11	133.5 ± 21.7	0.836
Hemoglobin (g/dL)	38	13.25 ± 1.46	11	12.31 ± 1.16	0.046
Hematocrit (%)	38	39.6 ± 4.2	11	37.2 ± 3.4	0.082
MCV (μm3)	36	84.32 ± 4.37	11	80.25 ± 5.52	0.072
Reticulocyte (%)	36	1.90 ± 3.02	10	1.37 ± 0.39	0.312
Height (cm)	35	163.2 ± 6.6	8	161.7 ± 6.4	0.589
Weight (kg)	37	69.7 ± 13.4	10	72.2 ± 14.9	0.640
Hb A1 (%)	38	96.16 ± 0.57	11	96.10 ± 0.51	0.757
Hb A2 (%)	38	2.88 ± 0.35	11	2.76 ± 0.41	0.401
Hb S (%)	0	0 ± 0	0	0 ± 0	NA
Hb F (%)	3	1.03 ± 0.32	0	0 ± 0	0.360
BMI (kg/m2)	33	25.6 ± 4.2	7	27.3 ± 5.6	0.472

HDL: High density lipoprotein; LDL: Low density lipoprotein; LDH: Lactate dehydrogenase; MCV: Mean corpuscular volume; Hb: Hemoglobin; Hb S: Sickle Hb; Hb F: Fetal Hb; BMI: Body mass index: NA: Not applicable.

Table 2 Predictive values of mean corpuscular volume and hemoglobin in determining hemoglobinopathies

Variable	Sensitivity	Specificity	Positive predictive value	Negative predictive value
MCV < 82 μm3	70.7	75.0	42.8	90.6
Hb < 12 g/dL	82.1	63.6	30.8	80.0

MCV: Mean corpuscular volume; Hb: Hemoglobin.

Table 3 Distribution of patients according to categorical variables n (%)

	Diagnosis		Total	P
	Normal	Suspected
BMI (kg/m2)
< 25	12 (80.0)	3 (20.0)	15	0.267
25-30	17 (89.5)	2 (10.5)	19
> 30	8 (61.5)	5 (38.5)	13
Hemoglobin (g/dL)
< 12	9 (69.2)	4 (30.8)	13	0.425
≥ 12	32 (80.0)	8 (20.0)	40
Gender
Female	37 (77.1)	11 (22.9)	48	0.883
Male	4 (80.0)	1 (20.0)	5
MCV (μm3)
< 82	12 (57.1)	9 (42.9)	21	0.007
≥ 82	29 (90.6)	3 (9.4)	32
No. of gallstones
Only one	2 (33.3)	4 (66.7)	6	0.004
2-5	4 (66.7)	2 (33.3)	6
Multiple	35 (85.4)	6 (14.6)	41
Total	41 (77.4)	12 (22.6)	53

MCV: Mean corpuscular volume; BMI: Body mass index.