HBV genotype C is independently associated with cirrhosis in community-based population

Table 1 Demographic and viral characteristics and liver abnormalities of 634 subjects seropositive for hepatitis B surface antigen n (%)

Variables	Genotype B (n = 199)	Genotype C (n = 411)	Others (n = 24)1	P value2
Age (yr)3	42.1 ± 13.0	41.3 ± 12.8	43.8 ± 12.8	0.493
Gender
Male	116 (58.3)	228 (55.5)	16 (66.7)
Female	83 (41.7)	183 (44.5)	8 (33.3)	0.511
ALT (log10 U/L)3	1.4 ± 0.3	1.4 ± 0.3	1.4 ± 0.2	0.238
≤ 45 U/L	174 (87.4)	373 (90.8)	23 (95.8)
> 45 U/L	25 (12.6)	38 (9.2)	1 (4.2)	0.207
HBeAg
Negative	186 (93.5)	385 (93.7)	24 (100.0)
Positive	13 (6.5)	26 (6.3)	0	0.922
HBV DNA levels (log10 copies/mL)3	3.7 ± 1.7	3.5 ± 1.7	3.1 ± 1.1	0.194
< 4	151 (75.9)	347 (84.4)	23 (95.8)
≥ 4	48 (24.1)	64 (15.6)	1 (4.2)	0.011
Fatty liver
Yes	16 (8.0)	24 (5.8)	2 (8.3)
No	183 (92.0)	387 (94.2)	22 (91.7)	0.303
Cirrhosis status
Normal	183 (92.0)	350 (85.2)	19 (79.2)
Probable cirrhosis4	16 (8.0)	61 (14.8)	5 (20.8)	0.018

¹23 cases for genotype mixture, 1 case for genotype D;

²Genotype C vs genotype B;

³mean ± SD;

⁴Ultrasonographic cirrhosis and cirrhosis-like ultrasonographic abnormalities (ultrasonographic score ≥ 5). ALT: Alanine aminotransferase; HBeAg: Hepatitis B e antigen; HBV: Hepatitis B virus.

Table 2 Univariate and multivariate regression analyses for the risk factors of probable liver cirrhosis in the 595 HBeAg negative subjects infected with HBV

Variables	Controls (n = 513)	Cases (n = 82)	OR (95% CI)	AOR (95% CI)
Age (yr)
< 45	284 (55.4)	31 (37.8)
≥ 45	229 (44.6)	51 (62.2)	2.04 (1.26-3.29)	1.81 (1.10-2.99)
Sex
Female	235 (45.8)	25 (30.5)
Male	278 (54.2)	57 (69.5)	1.93 (1.17-3.18)	1.74 (1.03-2.95)
ALT (U/L)
≤ 45	473 (92.2)	66 (80.5)
> 45	40 (7.8)	16 (12.9)	2.87 (1.52-5.41)	2.98 (1.48-5.99)
Viral load (Log10 copies/mL)
< 4	432 (84.2)	67 (81.7)
≥ 4	81 (15.8)	15 (18.3)	1.19 (0.65-2.19)	1.06 (0.54-2.08)
Genotype
B	170 (34.4)	16 (20.8)
C	324 (65.6)	61 (79.2)	2.00 (1.12-3.58)	2.30 (1.26-4.19)

AOR: Adjusted odds ratio; OR: Odds ratio.