Correlation between pre-miR-146a C/G polymorphism and gastric cancer risk in Chinese population

Table 1 The characteristics of cases and controls n (%)

Characteristics	Cases	Controls	P value
Overall	304	304
Gender (male)	228 (75)	228 (75)	1.000
Age1 (yr)	59 (51-66)	58 (50-66)	0.865
Hypertension	54 (17.76)	59 (19.41)	0.602
Diabetes	17 (5.59)	27 (8.88)	0.118
Smoking	73 (24.01)	58 (19.08)	0.111
Residence
Rural	158 (51.97)	165 (54.46)	0.540
Urban	146 (48.03)	138 (45.54)

¹Median (25th-75th percentiles).

Table 2 The pre-miR-146a C/G genotype distribution in cases and controls and risk estimates for variant genotypes

	Cases (%)	Controls (%)1	Crude OR (95% CI)	P value	Adjusted OR2 (95% CI)	P value
Genotype3 CC	89 (29.28)	119 (39.14)	1.00		1.00
CG	153 (50.33)	132 (43.42)	1.55 (1.08-2.22)	0.017	1.55 (1.07-2.22)	0.019
GG	62 (20.39)	53 (17.43)	1.56 (0.99-2.47)	0.056	1.62 (1.01-2.58)	0.045
GG + GC allele4	215 (70.72)	185 (60.85)	1.55 (1.11-2.18)	0.011	1.58 (1.12-2.22)	0.009
C-allele	331 (54.44)	370 (60.86)
G-allele	277 (45.56)	238 (39.14)

¹The genotype distributions complied well with Hardy-Weinberg equilibrium in cases and controls (P = 0.7993, P = 0.1223, respectively);

²Adjusted for age, sex, smoking status, hypertension, residence and diabetes;

³Pearson χ² = 6.5786, P = 0.037;

⁴Pearson χ² = 5.1232, P = 0.024.

Table 3 Stratified analyses for variant pre-miR-146a C/G genotypes in cases and controls

Variable	(GG + GC)/CC		Crude OR (95% CI)	P value	Adjusted OR1 (95% CI)	P value
	Cases	Controls
Age (median, yr)
≤ 58	105/42	93/63	1.69 (1.05-2.74)	0.031	1.76 (1.08-2.87)	0.024
> 58	110/47	92/56	1.42 (0.88-2.29)	0.145	1.43 (0.88-2.33)	0.147
Sex
Female	56/20	48/28	1.63 (0.82-3.26)	0.164	1.80 (0.88-3.67)	0.105
Male	159/69	137/91	1.53 (1.04-2.25)	0.031	1.53 (1.04-2.27)	0.033
Smoking status
Smokers	52/21	34/21	1.53 (0.73-3.22)	0.263	1.49 (0.69-3.21)	0.310
Non-smokers	163/68	151/95	1.51 (1.03-2.20)	0.035	1.55 (1.06-2.28)	0.025
Residence
Urban	114/44	103/62	1.56 (0.98-2.49)	0.063	1.58 (0.98-2.54)	0.058
Rural	101/45	81/57	1.58 (0.97-2.57)	0.066	1.58 (0.96-2.60)	0.074

¹Adjusted for age, sex, smoking status, hypertension, residence and diabetes.

Table 4 Associations between variant pre-miR-146a C/G genotypes and clinicopathological characteristics of gastric cancer

Variable	GG + CG	CC	Crude OR (95% CI)	P value	Adjusted OR (95% CI)1	P value
Tumor differentiation
Well	26	15	1.00		1.00
Moderate	123	42	1.69 (0.82-3.50)	0.157	1.60 (0.76-3.38)	0.216
Poor	60	31	1.12 (0.52-2.41)	0.779	1.06 (0.46-2.45)	0.894
Depth of tumor infiltration
T1	37	15	1.00		1.00
T2	25	11	0.92 (0.36-2.33)	0.863	0.90 (0.34-2.38)	0.839
T3	103	39	1.07 (0.53-2.16)	0.849	1.16 (0.57-2.39)	0.680
T4	44	23	0.78 (0.35-1.70)	0.525	0.78 (0.35-1.75)	0.547
Lymph node metastasis
Negative	74	33	1.00		1.00
Positive	135	55	1.09 (0.65-1.83)	0.732	1.09 (0.65-1.83)	0.746
Localization
Cardia	61	24	1.00		1.00
Non-cardia	154	65	0.93 (0.54-1.62)	0.804	0.89 (0.50-1.57)	0.683

Data of 7 plaintively treated cases was not obtained for the inoperable tumors.

¹Adjusted for age, sex, smoking status, hypertension, residence and diabetes.