High-sensitivity C-reactive protein in paediatric inflammatory bowel disease

Table 1 The background data of the paediatric IBD patients with CRP measurement at the time of the colonoscopy (n = 39)

UC	19
M/F	10/9
Pancolitis	16
Left-sided disease	3
CD	20
M/F	14/6
Ileocolitis	13
Colitis	7
Age (median, range, yr)	12.8 (1.9-18)
BMI (median, range, kg/m2)	18.40 (14.2-25)
Fresh diagnosis	20/39

Notably, all patients with Crohn’s disease presented with colitis. IBD: Inflammatory bowel disease; CRP: C-reactive protein; UC: Ulcerative colitis; CD: Crohn’s disease; BMI: Body mass index.

Table 2 The clinical characteristics of the 22 paediatric IBD patients followed for acute response to glucocorticoids

UC	14
M/F	9/5
Pancolitis	11
Left-sided disease	3
CD	7
M/F	5/2
Ileocolitis	2
Colitis	5
IC	1 male
Age (median, range, yr)	13.1 (3.5-18)
BMI (median, range, kg/m2)	16.9 (13.2-22.6)
Fresh diagnosis	7/22

IC: Indeterminate colitis.

Table 3 The assessment of the histology score[17]

Epithelial damage

0 Normal

1 Focal pathology

2 Extensive pathology

Architectural changes

0 Normal

1 Moderately (< 50%) disturbed

2 Severely (> 50%) disturbed

Infiltration of mononuclear cells in the lamina propria

0 Normal

1 Moderate increase

2 Severe increase

Infiltration of polymorphonuclear cells in the lamina propria

0 Normal

1 Moderate increase

2 Severe increase

Infiltration of polymorphonuclear cells in the epithelium

0 Normal

1 If in surface epithelium

2 If cryptitis

3 If a crypt abscess present

Presence of erosion or ulcers

0 No

1 Yes

The number of biopsy specimens affected

0 None

1 < 33%

2 33%-66%

3 > 66%

The score was calculated separately for each segment.

Table 4 The median (range) levels of inflammatory markers and histology score and their correlation with the CRP levels in 39 paediatric patients with IBD

	Median (range)	Correlation with CRP
Inflammatory markers
Calprotectin (n = 35)	690 μg/g (14-4400)	0.488b
ESR (n = 37)	18 mm/h (2-97)	0.618d
WBC (n = 38)	7.6 E9/L (3.2-17.4)	-0.011
Histology score
Ileum (n = 29)1	0 (0-15)	0.475a
Caecum (n = 38)	4 (0-14)	-0.036
Ascendens (n = 34)	4.5 (0-13)	-0.198
Transversum (n = 36)	6 (0-15)	-0.158
Descendens (n = 39)	6 (0-15)	-0.077
Sigma (n = 35)	5 (0-14)	-0.014
Rectum (n = 38)	5.5 (0-14)	-0.051
Total colon (n = 32)	30 (0-74)	-0.083

¹The histology score of the ileum was positive in only one UC patient (with backwash ileitis), all the other positive scores are from CD patients.

^aP < 0.05,

^bP < 0.01,

^dP < 0.001. ESR: Erythrocyte sedimentation rate; WBC: White blood cell count.