Relationship between clinicopathological features and mucin phenotypes of advanced gastric adenocarcinoma

Table 1 Clinical profiles and tumor characteristics according to the histological subtypes

Histological subtype	Gender		Age at operation (yr)	Tumor site			Tumor size (cm)
	Male	Female		U	M	L	< 5	> 5
DAC (n = 38)	28	10	58	9	12	17	17	21
SIG (n = 9)	3a	6a	62	2	1	6	3	6
Non-SIG (n = 48)	24	24	65	7	27	14	14	34

DAC: Differentiated-type adenocarcinoma; SIG: Signet-ring cell carcinoma; Non-SIG: Other diffuse-type adenocarcinomas; U: Upper segment of the stomach; M: Middle segment of the stomach; L: Lower segment of the stomach.

^aP = 0.05.

Table 2 Expression rates of the various mucin phenotypes at the intramucosal layer among patients classified according to the histological subtype

Antigen/histological subtype	HGM (%)	MUC5AC (%)	MUC6 (%)	M-GGMC-1 (%)	MUC2 (%)	CD10 (%)
DAC (n = 38)	97	95	84	90ab	76c	0
SIG (n = 9)	100	100d	56	44ad	33c	0
Non-SIG (n = 48)	96	98e	65	52be	56	0

HGM: Human gastric mucin.

^aP < 0.01,

^bP < 0.01,

^cP = 0.02,

^dP = 0.02,

^eP < 0.01.

Table 3 Expression rates of the various mucin phenotypes at the intramucosal layer of gastric adenocarcinomas according to the histological subtypes n (%)

Mucin phenotype/histological subtype	G	GI	I	UC
DAC (n = 38)	9/38 (24)	29/38 (76)ab	0/38 (0)	0/38 (0)
SIG (n = 9)	6/9 (67)	3/9 (33)a	0/9 (0)	0/9 (0)
Non-SIG (n = 48)	19/48 (40)	27/48 (56)b	0/48 (0)	2/48 (4)

G: Gastric phenotype; GI: Gastrointestinal phenotype; I: Intestinal phenotype; UC: Unclassified phenotype.

^aP = 0.02;

^bP = 0.06.

Table 4 Comparisons between the expression of G and GI phenotypes in clinical profiles, tumor site and tumor size, metastasis rate, and histological findings, according to the histological subtype

Histological subtype	DAC		SIG		Non-SIG
Mucin phenotype	G (n = 9)	GI (n = 29)	G (n = 6)	GI (n = 3)	G (n = 19)	GI (n = 27)
Male:female	6:3	12:17	0:6a	3:0a	9:10	10:17
Mean age (yr)	57.2	60.3	63.2	55.3	68.2	60.9
Tumor site
U	2	7	2	0	2	5
M	2	10	0	1	9	18
L	5	12	4	2	8	4
Tumor size (cm)
< 5	3	17	3	0	9b	3b
> 5	6	12	3	3	10b	24b
Metastasis rate (expression rate, %)
Lymph node	67	45	83	100	42c	81c
Other site	22	3	50	33	11	19
Histological findings (expression rate, %)
Vessel invasion	67	69	67	100	84	93
Lymph invasion	100	86	83	100	95	100

^aP = 0.01,

^bP = 0.01,

^cP = 0.01.