Prediction of disease course in inflammatory bowel diseases

Table 1 Predictors for long and short term disease course in inflammatory bowel diseases

Markers
Disabling/complicated disease in CD
Young age at onset (pediatric or < 40 yr)
Small bowel disease
Stricturing
Perianal disease
Weight loss > 5 kg
Steroid need for the first flare at diagnosis
Early immunosupression and/or biological therapy (protective?)
NOD2/CARD15
rs1363670 near IL12B
ASCA, glycans
Surgery in CD/colectomy in UC
Young age at onset (pediatric or < 40 yr)
Small bowel disease
Stricturing or penetratingat diagnosis
Early immunosupression and/or biological therapy (protective?)
Deep ulcers at endoscopy
ASCA, glycans
Extensive disease in UC
Smoking (protective) in UC
Clinical relapse
CRP, ESR
Calprotectin
Complete or partial mucosal healing (protective)

NOD2/CARD15: Nucleotide oligomerization domain2/caspase activation recruitment domain15; ASCA: Anti-Saccharomyces cerevisiae antibodies; CRP: C reactive protein; ESR: Erythrocyte sedimentation rate; UC: Ulcerative colitis; CD: Crohn’s disease.