Rate and yield of repeat upper endoscopy in patients with dyspepsia

Table 1 Characteristics of the study population n (%)

	Initial EGD (n = 451)	Repeat EGD (n = 451)
Age (yr, mean ± SD)	53.4 ± 18.8	55.6 ± 19.2
Gender
Female	285 (63)	285 (63)
Male	166 (37)	166 (37)
Time from first to second EGD [yr, median (interquartile range)]	--	1.7 (0.8-3.1)
Indications
Dyspepsia exclusively	255 (57)	253 (56)
Dyspepsia and additional indication(s)	196 (43)	198 (44)

EGD: Esophagogastroduodenoscopy.

Table 2 Indications for endoscopy n (%)

	Initial EGD (n = 451)	Repeat EGD (n = 451)
Dyspepsia	451 (100)	451 (100)
Dyspepsia	196 (44)	159 (35)
Abdominal pain	168 (37)	199 (44)
Abdominal pain despite treatment	115 (26)	103 (23)
Abdominal pain suggesting organic disease	10 (2)	17 (4)
Bloating	11 (2)	24 (5)
Additional Indications	196 (43)	198 (44)
Abnormal imaging study	1 (0.2)	2 (0.4)
Anemia or gastrointestinal bleeding	27 (6)	15 (3)
Anorexia and/or weight loss	17 (4)	16 (4)
Dysphagia	68 (15)	42 (9)
Gastroesophageal reflux disease symptoms	56 (12)	77 (17)
Nausea and/or vomiting	26 (6)	33 (7)
Follow-up of ulcer	9 (2)	5 (1)
Follow-up of Barrett’s esophagus	5 (1)	8 (2)
Cirrhosis-related	1 (0.2)	1 (0.2)
Diarrhea	22 (5)	20 (4)
Miscellaneous1	12 (3)	16 (4)

¹Includes planned dilation, evaluation for graft-versus-host disease, fever, postoperative evaluation, family history of malignancy, and “surveillance”.

Table 3 Findings at endoscopy n (%)

	Initial EGD (n = 451)	Repeat EGD (n = 451)
Esophagitis	95 (21)	59 (13)
Hiatal hernia	160 (36)	172 (38)
Esophageal stricture	13 (3)	10 (2)
Gastritis	221 (49)	196 (43)
Gastric erosions	44 (10)	40 (9)
Gastric ulcer	31 (7)	14 (3)
Gastric polyps	21 (5)	21 (5)
Duodenitis	35 (8)	24 (5)
Duodenal erosions	6 (1)	3 (0.7)
Duodenal ulcer	13 (3)	8 (2)
Duodenal stricture	2 (0.5)	3 (0.7)
Retained food suggesting gastroparesis	2 (0.5)	8 (2)
Postoperative changes	11 (2)	18 (4)
Biopsy-proven malignancy	0 (0)	0 (0)
Biopsy-proven Barrett’s esophagus (new diagnosis)	3 (0.7)	3 (0.7)
Significant finding possibly related to dyspepsia1	133 (29)2	79 (18)2

¹Defined as esophagitis, gastric or duodenal ulcer, or biopsy-proven malignancy. The sum of these individual findings in the table is higher than this cumulative value because some patients had more than one individual finding;

²Odds ratio, 1.45; 95% confidence interval: 1.20-1.75, P < 0.0001.