EZH2 and STAT6 expression profiles are correlated with colorectal cancer stage and prognosis

Table 1 Relationship between EZH2 or STAT6 and clinicopathological features

	Cases	EZH2 expression		P	STAT6 expression		P
		EZH2+	EZH2-		STAT6+	STAT6-
Tissue
Non-neoplastic samples		22	97	0.000	50	69	0.004
Tumor samples		83	36		72	47
Gender
Female	47	30	17	0.334	24	23	0.089
Male	72	52	20		48	24
Location
Colon	90	62	28	0.719	57	33	0.268
Rectum	29	21	8		15	14
Differentiation
Poor	21	16	5	0.479	16	5	0.101
Moderate or well	98	67	31		56	42
TNM classification
I	11	4	7	0.049	3	8	0.004
II	42	29	13		20	22
III	44	35	9		32	12
IV	22	15	7		17	5
Depth of wall invasion
T1	1	1	0	0.014	1	0	0.188
T2	19	9	10		8	11
T3	93	71	22		58	35
T4	6	2	4		5	1
Lymph node metastasis
No	55	34	21	0.081	25	30	0.001
Yes	64	49	15		47	16
Distant metastasis
M0	97	66	31	0.668	54	43	0.024
M1	22	16	6		18	4
Recurrence
No	86	61	25	0.088	53	33	0.775
Yes	11	6	5		4	7

Table 2 Multivariate analysis of prognostic factors in 119 cases using the Cox proportional hazard model

	B	P	RR	95% CI for RR
				Lower	Upper
Metastasis	3.075	0.000	21.648	8.212	57.070
Lymph node metastasis	1.149	0.018	3.157	1.218	8.178
Grading	-0.675	0.051	0.509	0.258	1.003
Recurrence	0.510	0.173	1.665	0.799	3.469
EZH2	1.167	0.039	3.214	1.061	9.732

B: Regression coefficient.

Table 3 Relationship between EZH2 and STAT6 expressions

EZH2	STAT6		Total
	+	-
+	59	24	83
-	13	23	36
Total	72	47	119

r_s = 0.329, P = 0.00.

Table 4 Relationship between EZH2 and STAT6 co-expression and TNM classification

TNM classification	EZH2 and STAT6 expressions				EZH2+ and STAT6+ expression in different stages(%)
	EZH2+ and STAT6+	EZH2-or STAT6-	EZH2- and STAT6-	Total
I	2	3	6	11	18
II	15	19	8	42	40
III	26	10	8	44	59
IV	16	5	1	22	72
Total	59	37	23	119	49

P = 0.003.