Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains

Table 1 MICs and amino acid changes in quinolone-resistant and susceptible strains of H. pylori

Strains	MIC (μg/mL)			Mutations of GyrA	Mutations of GyrB
	LVX	MOX	CIP
1R1	1.5	2	32	Asp91Gly and Val150Ala	0
2R1	2	2	32	Asp91Asn	0
3R1	2	2	32	Asp91Gly	0
4R1	3	1.5	1.5	Asp91Asn	Ser457Ala
5R1	4	3	4	Asp91Tyr	0
6R	4	3	32	Asp91Asn	0
7R1	6	4	32	Asp91Asn	0
8R	6	6	12	Asn87Lys and Arg140Lys	0
9R	8	4	12	Asn87Tyr	0
10R	12	8	32	Asp91Gly	0
11R	12	12	12	Asn87Ile and Arg140Lys	0
12R1	12	12	32	Asp91Asn	0
13R	32	12	32	Asn87Tyr	0
14R1	32	16	32	Asp91Asn	0
15R1	32	32	32	Asp91Asn	0
16R1	32	32	32	Asn87Ile	0
17R	32	32	32	Asn87Ile and Val150Ala	0
18R1	32	32	32	Asn87Lys	0
19R1	32	32	32	Asn87Lys	0
20R	32	32	32	Asn87Lys	0
21R	32	32	32	Asn87Lys	0
22R	32	32	32	Asn87Lys	0
23R	32	16	8	Asn87Lys	0
24R	24	32	32	Asn87Lys	0
25R	12	12	32	Asn87Lys	0
26R	6	6	32	Asn87Lys	0
27R	3	6	12	Asn87Lys	0
1S	0.02	0.02	0.016	Val150Ala	0
2S	0.016	0.016	0.032	Ala97Thr	0
3S	0.064	0.094	0.064	Arg140Lys	0
4S	0.064	0.02	0.023	0	Val451Gly

¹Primary resistance. R: Resistant strains; S: Susceptible strains; 0: No mutation; MIC: Minimal inhibitory concentration; LVX: Levofloxacin; MOX: Moxifloxacin; CIP: Ciprofloxacin; H. pylori: Helicobacter pylori.

Table 2 MICs and amino acid changes in quinolone strains of H. pylori with no QRDR mutations

Strains	MIC (μg/mL)			Mutations of GyrA	Mutations of GyrB
	LVX	MOX	CIP
28R1	24	16	32	0	0
29R1	16	32	32	0	0

¹Primary resistance. QRDR: Quinolone resistance-determining region.