Treatment outcome of localized Helicobacter pylori-negative low-grade gastric MALT lymphoma

Table 1 Baseline characteristics of H. pylori-negative low-grade gastric MALT lymphoma n (%)

	H. pylori negative MALT lymphoma (n = 11)
Age (yr, mean)	55.7 (36-73)
Sex
Men	5 (45)
Women	6 (55)
Site
Cardia	1 (9)
Fundus	1 (9)
Body only	3 (27)
Body & antrum	4 (36)
Diffuse	2 (18)
Endoscopy
Ulcerative	5 (45)
Infiltrative	1 (9)
Protruding	2 (18)
Granular	1 (9)
Mixed	2 (18)

H. pylori: Helicobacter pylori; MALT: Mucosa-associated lymphoid tissue.

Table 2 Individual characteristics of 11 cases of H. pylori-negative low-grade gastric MALT lymphoma

	Age (yr)/sex	Stage	Treatment	Response	Time to CR(mo)	Follow up time after remission (mo)
Case 1	54/F	IE	Eradication	CR	1	6
Case 2	60/F	IE	Eradication	CR	1	27
Case 3	52/F	IE	Eradication	CR	2	25
Case 4	36/M	IE	RTx	CR	1	76
Case 5	58/F	IE	RTx	CR	2	17
Case 6	69/M	IE	RTx	CR	1	47
Case 7	41/F	IE	Eradication + RTx	CR	1	7
Case 8	62/M	IE	Eradication + RTx	CR	1	8
Case 9	55/M	IE	Eradication -> RTx	CR	1	5
Case 10	73/F	IE	STG	CR	66	54
Case 11	53/M	IE	EMR	CR	2	69

CR: Complete remission; RTx: Radiotherapy; STG: Subtotal gastrectomy; EMR: Endoscopic mucosal resection.

Table 3 Efficacy of eradication treatment in H. pylori-negative gastric MALT lymphoma reported in the literature n (%)

Author	Yr	No. of patients	Stage	Follow-up after treatment (mo)	Response rate
Steinbach et al[17]	1999	6	IE	5 or more	0 (0)
Ye et al[18]	2003	5	IE	4-12	0 (0)
Raderer et al[16]	2006	6	IE	12-19	5 (83)
Stathis et al[23]	2009	14	IE	Not described	51 (35)
Ruskone-Fourmestraux et al[24]	2001	10	IE, IIE1	2-21	0 (0)
Nakamura et al[25]	2006	7	IE, IIE1	1-15	2 (29)
Akamatsu et al[21]	2006	9	IE, IIE1	6 or more	1 (11)
Terai et al[26]	2008	4	IE, IIE1	Not described	1 (25)

¹3 presented a local relapse.

Table 4 Efficacy of radiotherapy for H. pylori-negative gastric MALT lymphoma reported in the literature

Author	Yr	No. of patients	Stage	Follow-up after treatment, median (mo)	Response rate (%)
Schechter et al[27]	1998	12	IE, IIE	Not described	100
Ye et al[18]	2003	11	IE	12	100
Akamatsu et al[21]	2006	12 (51)	IE, IIE1	Not described	100
Chung et al[22]	2009	4	IE, IIE	12-39	100

¹Failure of anti-H. pylori treatment as the initial therapy.