Direct in vivo injection of 131I-GMS and its distribution and excretion in rabbit

Table 1 Effect of washing on labeling rate (n = 6)

Number of washes	Labeling rate (%)
0	68.01 ± 2.09
1	47.74 ± 2.26
2	43.68 ± 2.19
3	42.72 ± 2.23
4	42.22 ± 2.27
5	41.91 ± 2.28
6	41.56 ± 2.27
7	41.00 ± 2.29

Table 2 Ratio of radioactivity between the liver and thyroid (n = 6) after the administration of ¹³¹I-labeled gelatin microspheres

Time	Liver/thyroid
4 h	15.910 ± 0.740
Day 4	27.197 ± 5.467
Day 8	81.467 ± 24.637
Day 16	91.670 ± 23.278
Day 24	93.601 ± 21.337
Day 32	112.608 ± 12.787
Day 48	162.875 ± 7.955

Table 3 Effects of the administration of ¹³¹I-labeled gelatin microspheres on hepatic function (n = 4)

	ALT (IU/L)	AST (IU/L)	ALP (IU/L)	GGT (IU/L)	TP (g/L)	ALB (g/L)	GLB (g/L)
Before administration	67.75 ± 11.87	55.00 ± 11.87	99.75 ± 14.99	6.00 ± 1.83	54.33 ± 3.16	46.05 ± 2.32	8.28 ± 2.79
After administration
1 d	291.50 ± 12.79	146.00 ± 13.88	115.00 ± 25.92	9.25 ± 3.30	60.23 ± 1.96	45.65 ± 5.17	15.00 ± 5.34
4 d	46.75 ± 4.79	41.25 ± 10.69	91.00 ± 29.59	7.25 ± 1.26	58.43 ± 8.45	47.55 ± 3.53	12.23 ± 5.03
8 d	48.50 ± 14.39	48.00 ± 17.32	79.75 ± 14.77	7.50 ± 0.58	58.10 ± 4.40	44.63 ± 2.33	13.65 ± 4.33
16 d	37.25 ± 9.32	39.75 ± 11.81	76.00 ± 9.83	9.50 ± 3.11	62.13 ± 5.84	44.38 ± 7.41	19.85 ± 6.79
24 d	46.50 ± 16.01	45.25 ± 9.95	96.25 ± 17.08	8.00 ± 2.83	60.28 ± 4.45	47.60 ± 7.38	14.50 ± 3.54
32 d	52.25 ± 14.29	46.25 ± 8.66	96.75 ± 35.58	12.50 ± 3.87	63.55 ± 4.90	46.40 ± 4.06	18.63 ± 6.72
48 d	43.75 ± 10.01	40.25 ± 14.45	97.25 ± 7.93	9.25 ± 1.71	60.78 ± 4.08	46.83 ± 4.06	14.23 ± 4.22
64 d	45.50 ± 4.80	45.75 ± 3.24	91.75 ± 29.62	10.50 ± 3.42	61.92 ± 8.18	50.15 ± 5.30	15.05 ± 3.89

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; GGT: γ-glutamyltransferase; TP: Total protein; ALB: Albumin; GLB: Globulin.

Table 4 Effects of the administration of ¹³¹I-labeled gelatin microspheres on thyroid function (n = 4)

	FT3 (pmol/L)	FT4 (pmol/L)	TSH (mU/L)
Before administration	5.55 ± 0.57	19.61 ± 1.54	< 0.005
After administration
1 d	4.54 ± 1.53	19.31 ± 6.47	< 0.005
4 d	5.09 ± 1.68	21.31 ± 4.68	< 0.005
8 d	3.29 ± 0.83	14.23 ± 2.81	< 0.005
16 d	5.53 ± 1.01	19.95 ± 2.56	< 0.005
24 d	5.31 ± 0.57	20.39 ± 2.38	< 0.005
32 d	4.66 ± 2.17	19.18 ± 2.98	< 0.005
48 d	6.02 ± 2.77	20.94 ± 10.78	< 0.005
64 d	5.34 ± 1.34	21.23 ± 3.42	< 0.005

FT3: Free triiodothyronine; FT4: Free thyroxin; TSH: Thyrotropic-stimulating hormone.