Risk factors and therapeutic response in Chinese patients with peptic ulcer disease

Table 1 Clinical features of the two groups of patients at examination n (%)

	Upper endoscopy finding		Total	P-value
	Gastric ulcers	Duodenal ulcers
Case numbers (prevalence)	254 (56.6)	194 (43.4)	448 (100)
Age (yr)	60.44 ± 15.27	51.99 ± 16.24		0.0011
Gender
Male	142 (55.8)	110 (56.7)	252 (56.2)	0.8662
Female	112 (44.1)	84 (43.3)	196 (43.8)
H. pylori
Positive	110 (43.3)	121 (62.4)	231 (56.7)	0.0012
Negative	144 (56.7)	73 (37.6)	217 (43.3)
Smoking
Yes	36 (14.2)	31 (16.0)	67 (15.8)	0.5952
No	218 (85.8)	163 (84.0)	381 (86.0)
Alcohol
Yes	21 (8.3)	22 (11.3)	43 (9.6)	0.2742
No	233 (91.7)	172 (88.7)	405 (90.4)
Co-medications
Nil	218 (85.8)	187 (96.4)	405 (90.4)	0.0012
Aspirin	19 (7.5)	3 (1.5)	22 (4.9)
NSAIDs	17 (6.7)	4 (2.1)	21 (4.7)

¹t test;

²Pearson’s χ² test. NSAIDs: Nonsteroidal anti-inflammatory drugs.

Table 2 The impact of therapeutic efficacy according to H. pylori infection and ulcer location of patients n (%)

	Therapeutic efficacy		Total	P-value
	Ulcer healed	Ulcer unhealed
H. pylori
GU
Positive infections	77 (70.6)	32 (29.4)	109	0.661
Negative infections	99 (68.3)	46 (31.7)	145
DU
Positive infections	87 (71.9)	34 (28.1)	121	0.505
Negative infections	55 (75.3)	18 (24.7)	73
Medications
GU
Treat with PPI	131 (79.4)	34 (20.6)	165	0.007
Treat with H2RA	56 (62.9)	33 (37.1)	89
DU
Treat with PPI	115 (78.2)	32 (21.8)	147	0.430
Treat with H2RA	34 (72.3)	13 (27.7)	47

All analyzed with Pearson’s χ² test. GU: Gastric ulcer; DU: Duodenal ulcer; PPI: Proton-pump inhibitor; H2RA: H2-receptor antagonist.

Table 3 The impact of therapeutic efficacy according to co-medications and ulcer location of patients n (%)

Co-medications	Therapeutic efficacy		Total	P-value
	Ulcer healed	Ulcer unhealed
None
Positive H. pylori infection	159 (75.7)	51 (24.3)	210	0.370a
Negative H. pylori infection	140 (71.8)	55 (28.2)	195
ASP
Positive H. pylori infection	8 (80)	2 (20)	10	0.195b
Negative H. pylori infection	12 (100)	0	12
NSAID
Positive H. pylori infection	6 (60)	4 (40)	10	0.035b
Negative H. pylori infection	11 (100)	0	11

^aPearson’s χ² test;

^bFisher’s exact test. ASP: Aspirin.