Clinicopathological significance and prognostic value of LRP16 expression in colorectal carcinoma

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Apr 7, 2010 (publication date) through Oct 26, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 7, 2010; 16(13): 1644-1648
Published online Apr 7, 2010. doi: 10.3748/wjg.v16.i13.1644

Table 1 Correlation between LRP16 expression and clinicopathological factors in colorectal cancer n (%)

Variables	LRP16		Statistical value
Variables	Positive group (n = 197)	Negative group (n = 139)	Statistical value
Gender
Male	78 (61.4)	49 (38.6)	χ² = 1.460^a
Female	39 (52.7)	35 (47.3)	P = 0.227
Age (yr)
< 45	20 (64.5)	11 (35.5)	χ² = 0.640^a
45 ≤n < 60	36 (58.0)	26 (42.0)	P = 0.726
≥ 60	61 (56.5)	47 (43.5)
Tumor size (cm)
d < 5	68 (50.0)	68 (50.0)	χ² = 13.604^a
5 ≤ d < 10	42 (72.4)	16 (27.6)	P = 0.001
d ≥ 10	7 (100.0)	0 (0.0)
Tumor location
Cecum	5 (55.6)	4 (44.4)	χ² = 6.027^a
Ascending colon	22 (75.9)	7 (24.1)	P = 0.304
Transverse colon	8 (57.1)	6 (42.9)
Descending colon	6 (66.7)	3 (33.3)
Sigmoid colon	29 (60.4)	19 (39.6)
Rectum	47 (51.1)	45 (48.9)
Histologic differentiation
Well differentiated	12 (50.0)	12 (50.0)	χ² = 9.210^a
Moderately differentiated	56 (50.9)	54 (49.1)	P = 0.010
Poorly differentiated	49 (73.1)	18 (226.9)
Depth of invasion, T stage
T1	2 (28.6)	5 (71.4)	χ² = 25.470^a
T2	25 (36.8)	43 (63.2)	P = 0.001
T3	79 (69.9)	34 (30.1)
T4	11 (84.6)	2 (15.4)
Lymph node metastasis
LN = 0	58 (45.3)	70 (54.7)	χ² = 24.735^a
LN = 1-3	43 (78.2)	12 (21.8)	P = 0.001
LN > 3	16 (88.9)	2 (11.1)
Distant metastasis
Negative	107 (56.3)	83 (43.7)	χ² = 5.115^a
Positive	10 (90.9)	1 (9.1)	P = 0.027
TNM stage
I-II	52 (43.3)	68 (57.7)	χ² = 27.088^a
III-IV	65 (80.2)	16 (19.8)	P = 0.001

^aP < 0.05, statistically significant. LRP16: Leukemia related protein 16.

Table 2 Cox regression analysis of prognostic factors in colorectal carcinoma

Prognostic variables	B	SE	Wald value	P value	RR
Gender	0.261	0.197	1.756	0.185	1.298
Age (yr)	0.191	0.124	2.366	0.124	1.211
Tumor location	0.071	0.060	1.338	0.239	1.074
Histologic differentiation	0.747	0.162	21.128	0.001	2.110
Tumor size	0.123	0.188	0.433	0.510	1.131
Depth of invasion	0.508	0.199	6.523	0.011	1.661
Lymph node metastasis	0.060	0.206	0.085	0.771	1.062
Distant metastasis	1.450	0.526	7.589	0.006	4.264
TNM stage	0.717	0.236	9.236	0.002	2.049
LRP16 expression	0.741	0.225	10.868	0.001	2.099

B: Partial regression coefficient; RR: Relative risk. P < 0.05, statistically significant.

Citation: Xi HQ, Zhao P, Han WD. Clinicopathological significance and prognostic value of LRP16 expression in colorectal carcinoma. World J Gastroenterol 2010; 16(13): 1644-1648
URL: https://www.wjgnet.com/1007-9327/full/v16/i13/1644.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i13.1644