Role of BMP3 in progression of gastric carcinoma in Chinese people

Table 1 Relation of genetic instability and methylation of BMP3 gene with clinicopathological features of gastric cancer

Clinicopathological features	MSI		LOH
	%	(+/n)	%	(+/n)
Differentiation degree	16.00	(8/50)	20.00	(10/50)
High differentiation	25.00	(2/8)	0.00	(0/8)
Middle differentiation	8.69	(2/23)	21.74	(5/23)
Low differentiation	21.05	(4/19)	26.32	(5/19)
Serosa infiltration
Positive	17.15	(6/35)	22.86	(8/35)
Negative	13.33	(2/15)	13.33	(2/15)
Lymph node metastasis
Positive	12.12	(4/33)	30.30	(10/33)
Negative	23.53	(4/17)	0.00b	(0/17)
TNM stage
I + II	15.16	(5/33)	6.06	(2/33)
III + IV	17.65	(3/17)	47.05c	(8/17)

^bP < 0.001 vs positive lymph node metastasis;

^cP = 0.01 vs TNM stages I + II.

MSI: Microsatellite instability; LOH: Loss of heterozygosity; BMP3: Bone morphogenetic protein 3; TNM: Tumor, node and metastasis.

Table 2 Relation between BMP3 gene methylation and clinicopathological features of gastric cancer

Clinicopathological features	Methylation frequency		P value
	%	(+/n)
Differentiation degree	64.44	(29/45)
High	75.00	(6/8)
Middle	68.18	(15/22)	0.273
Low	53.33	(8/15)
Serosa infiltration
Positive	59.38	(19/32)	0.275
Negative	76.92	(10/13)
Lymph node metastasis
Positive	62.07	(18/29)	0.663
Negative	68.75	(11/16)
TNM stage
I + II	62.50	(10/16)	0.844
III + IV	65.52	(19/29)
MSI
Negative	71.05	(27/38)	0.031a
Positive	28.58	(2/7)
LOH
Negative	68.57	(24/35)	0.290
Positive	50.00	(5/10)

^aP < 0.05.