Liver histology according to the presence of metabolic syndrome in nonalcoholic fatty liver disease cases

Table 1 Presence of metabolic risk factors and liver histology (steatosis/necroinflammation) in NASH cases

	NASH patients (n = 69)
	Fatty infiltration			Necroinflammation
	Mild (%)	Moderate (%)	Severe (%)	Mild (%)	Moderate(%)	Severe (%)
Gender
Male	37.1	40.0	22.9	31.4	62.9	5.7
Female	41.2	35.3	23.5	20.6	64.7	14.7
Hepatomegaly
(+)1	31.3	37.5	31.2	25.0	62.5	12.5
(-)1	38.5	38.5	23.0	27.0	61.5	11.5
Body mass index
18.5-24.9	0	66.6	33.4	33.4	33.3	33.3
25-29.9	35.3	41.2	23.5	26.5	64.7	8.8
30-39.9	46.5	25.0	28.5	28.6	57.1	14.3
> 40	25.0	75.0	0	25.0	75.0	0
Central obesity
(+)	38.8	40.8	20.4	26.5	63.3	10.2
(-)	35.0	30.0	35.0	30.0	55.0	15.0
Hypertension
(+)	33.4	33.3	33.3	19.0	62.0	19.0
(-)	39.6	39.	20.8	33.3	58.3	8.4
Diabetes
(+)	40.0	35.0	25.0	33.4	57.1	9.5
(-)	38.7	38.7	22.6	30.7	59.1	10.2
Hypertriglyceridemia
(+)	36.2	34.0	29.8	21.4	63.8	14.8
(-)	41.0	54.5	4.5	41.0	54.5	4.5
Insulin resistance
(+)	33.3	36.7	30.0	13.3	73.4	13.3
(-)	43.5	34.7	21.8	47.8	43.5	8.7

¹(+): Present; (-): Absent. Presence of hypertriglyceridemia and insulin resistance seemed to increase the severity of steatosis and necroinflammation but these findings were not significant.

Table 2 Presence of metabolic risk factors and liver histology (stage) in NASH cases

	NASH patients (n = 70)1
	Fibrosis				Cirrhosis (%)
	Absent (%)	Perisinusoidal/Pericellular (%)	Periportal (%)	Bridging (%)
Gender
Male	51.4	23.0	14.3	8.60	2.70
Female	38.2	47.0	5.9	8.90	-
Hepatomegaly
(+)2	44.1	31.2	6.3	12.5	5.90
(-)2	44.3	36.5	13.5	7.70	-
Body mass index
18.5-24.9	33.3	0	33.3	33.3	-
25-29.9	38.2	44.1	11.7	5.8	-
30-39.9	46.4	25.0	14.2	10.7	3.12
> 40	25.0	75.0	0	0	-
Central obesity
(+)	46.9	30.6	16.3	6.1	2.04
(-)	65.0	20.0	10.0	5	-
Hypertension
(+)	47.8	42.8	4.7	4.7	-
(-)	58.4	24.4	12.7	4.5	2.04
Diabetes
(+)	28.5	38.0	14.2	14.2	4.76
(-)	53.1	25.5	12.7	8.5	-
Hypertrigly-ceridemia
(+)	50.0	25.0	15.6	9.3	-
(-)	59.3	31.2	6.2	3.1	4.34
Insulin resistance
(+)	53.3	36.6	13.3	3.3	3.33
(-)	65.7	18.4	10.5	2.6	-

¹69 patients with NASH and 1 cirrhotic patient; ²(+): Present; (-): Absent. Presence of diabetes and insulin resistance seemed to increase the severity of fibrosis, but these findings were not significant.

Table 3 Dual combinations of risk factors and liver histology in NASH cases

Liver histology	NASH cases
	Ob + DM (n = 6)	Ob + Htg (n = 8)	DM + Htg (n = 2)
Grade
1	3	2	0
2	2	6	1
3	1	0	1
Stage
0	1	3	0
1	4	4	1
2	1	0	0
3	0	1	1
4	0	0	0

Ob: Obesity; DM: Diabetes mellitus; Htg: Hypertriglyceridemia. Dual combination of risk factors did not seem to effect liver histology.

Table 4 Liver histology according to the presence of metabolic syndrome in NASH cases (%)

Liver histology	Patients with NASH (n = 69)
	With metabolic syndrome (n = 46, 66.6%)	Without metabolicsyndrome (n = 23, 33.4%)
Fatty infiltration
Mild	20 (43.4)	11 (47.8)
Moderate	19 (41.3)	6 (26.1)
Severe	7 (15.3)	6 (26.1)
Necroinflammation
Absent	0 (0)	0 (0)
Mild	13 (28.3)	9 (39.1)
Moderate	28 (60.9)	13 (56.5)
Severe	5 (10.8)	1 (4.40)
Fibrosis
Absent	20 (43.4)	9 (39.1)
Perisinusoidal/pericellular	16 (34.7)	9 (39.1)
Periportal	7 (15.4)	2 (8.60)
Bridging	3 (6.50)	3 (13.2)
Cirrhosis	1 (2.12)	0 (0)

Evaluations were performed using percentage values. Presence of metabolic syndrome seemed to increase the severity of steatosis, necroinflammation and fibrosis in liver, but these results were not significant as well.