Furazolidone, amoxicillin, bismuth and rabeprazole quadruple rescue therapy for the eradication of Helicobacter pylori

Table 1 Baseline characteristics of patients (mean ± SD)

Group	No. of patients	Age (yr)	Male	Gastritis	Ulcer (DU/GU)	Smoking	Drinking
A	20	49.3 ± 15.2	8	11	8 (7/1)	6	3
B	20	49.9 ± 21.5	12	13	9 (8/1)	6	5
C	20	48.1 ± 9.3	8	12	7 (7/0)	6	3
Total	60	49.1 ± 15.8	28	36	24	18	9
χ2 value	-	-	2.14	0.42	0.42	0.00	0.89
P value	-	-	> 0.05	> 0.05	> 0.05	> 0.05	> 0.05

Table 2 H pylori eradication rates among three treatment groups

Group	Eradication	Non-eradication	Lost	Total	Eradication ratea (PP, %) (95% CI, %)	Eradication rateb (ITT, %) (95% CI, %)
A	14	3	3	20	82 (57-96)	70 (46-88)
B	17	2	1	20	89 (67-99)	85 (62-97)
C	18	2	0	20	90 (68-99)	90 (68-99)
Total	48	7	4	60	87 (78-96)	80 (70-90)

^aχ² = 0.59, P > 0.05;

^bχ² = 2.89, P > 0.05.

Table 3 H pylori eradication rates in relation to course of previous treatment

Times of failure	Eradication	Non-eradication	Lost	Total	Eradication ratea (PP,%) (95% CI, %)	Eradication rateb (ITT, %) (95% CI, %)
1	35	5	2	42	88 (73-96)	83 (74-96)
2	13	1	2	16	93 (66-100)	81 (54-96)
3	1	1	0	2	50 (1-99)	50 (1-99)
Total	48	7	4	60	87 (78-96)	80 (70-90)

^aχ² = 2.94, P > 0.05;

^bχ² = 1.42, P > 0.05.

Table 4 Side-effect profile of patients n (%)

Side effects	Group A	Group B	Group C	Total
Nausea	2	1	2	5 (8.3)
Diarrhea	1	1	1	3 (5.0)
Bowel movement increasing	0	1	1	2 (3.3)
Dizziness	0	0	2	2 (3.3)
Headache	0	0	1	1 (1.7)
Asthenia	1	0	0	1 (1.7)
Total episodes	4	3	7	14 (23.3)
Total patients1	2 (10)	3 (15)	6 (30)	11 (18.3)

Two patients got two kinds of side effects in group A and group C, respectively;

¹χ² = 2.89, P > 0.05.