Serum biomarker tests are useful in delineating between patients with gastric atrophy and normal, healthy stomach

Table 1 Prevalence of patients in different gastritis categories. Comparison between GastroPanel examination and biopsy histology

GastroPanel	Histology
	C	AC	A	S	N	Total
C	3	0	0	4	0	7
AC	1	2	0	0	0	3
A	0	1	1	5	0	7
S	3	1	5	73	3	85
N	0	2	1	4	53	60
Total	7	6	7	86	56	162

Accuracy: 87%; sensitivity: 40%; specificity: 94%; C, AC, A: Moderate or severe atrophic gastritis in corpus alone, in antrum and corpus simultaneously, and in antrum alone, respectively; S: Non-atrophic H pylori gastritis; N: Normal and healthy stomach mucosa.

Table 2 Prevalence of patients in corpus atrophy positive (AG+) and negative (AG-) categories if “strict” criteria for cut-off of positive Pg test (Pg test+ versus Pg test-) are used. Comparison between Japanese Pepsinogen test and biopsy histology

	AG+	AG-	Total
Pg test+	9	6	15
Pg test-	11	136	147
Total	20	142	162

AG: Atrophic corpus gastritis present (+) or absent (-). Pg: Pepsinogen test positive (+) or negative (-) for atrophic corpus gastritis.

Table 3 Sensitivity and specificity of the Japanese pepsinogen test and GastroPanel examination in atrophic gastritis if the cut-offs (criteria) for the positive pepsinogen test result are set to be mild, moderate or strict (%)

Pepsinogen test criteria	Sensitivity	Specificity
Japanese-mild	75	69
Japanese-moderate	65	77
Japanese-strict	45	96
Gastropanel-strict	40	94

Table 4 Prevalence of patients in categories of “healthy” or “diseased” gastric mucosa. Comparison between GastroPanel examination and biopsy histology

GastroPanel	Histology
	Healthy stomach mucosa	Diseased stomach mucosa	Total
Healthy stomach mucosa	53	7	60
Diseased stomach mucosa	3	99	102
Total	56	106	162

Accuracy: 94%; sensitivity: 95%; specificity: 93%.