Usefulness of anti-ulcer drugs for the prevention and treatment of peptic ulcers induced by low doses of aspirin

Table 1 Classification of endoscopic findings according to the Lanza score[5]

Score	Endoscopic findings
0	No lesion
1	Hemorrhagic erosion
2	One or two erosions
3	3-10 erosions
4	More than 10 erosions
5	Ulcer

Table 2 Anti-ulcer drugs used in patients enrolled in study-1

Type of drug	Drug name	Doses (/day)	Number of patients
None			34
PPIs			8
	Rabeprazole sodium	10 mg	3
	Lansoprazole	30 mg	2
	Lansoprazole	15 mg	1
	Omeprazole	20 mg	2
H2RAs			16
	Famotidine	40 mg	1
	Famotidine	20 mg	8
	Famotidine	10 mg	1
	Lafutidine	20 mg	2
	Nizatidine	300 mg	2
	Ranitidine hydrochloride	75 mg	1
	Cimetidine	100 mg	1
Cytoprotective anti-ulcer drugs			10
	Rebamipide	300 mg	2
	Rebamipide	200 mg	1
	Rebamipide	100 mg	1
	Azulensulfonate sidium + L-Glutamine	2 g	2
	Teprenone	1.5 g	1
	Polaprezinc	150 mg	1
	Sofalcone	300 mg	1
	Alginate sodium	180 mL	1

Table 3 Endoscopic findings classified according to the Lanza score in patients receiving low-dose aspirin with or without anti-ulcer drugs

Number of patients	Sex M:F	Age (yr)(mean ± SD)	Lanza scores (Number of patients)						Mean scores
			0	1	2	3	4	5
No anti-ulcer drugs
34	24:10:00	69.4 ± 11.2	1	0	1	0	1	31	4.741
Cytoprotective drugs
10	8:02	67.9 ± 8.6	1	0	0	1	0	8	4.301
H2RAs
16	7:09	67.8 ± 14.0	7	3	1	0	0	5	1.881
At regular doses
5	2:03	69.6 ± 10.8	2	1	1	0	0	1	1.601
Less than regular doses
11	5:06	66.9 ± 15.6	5	2	0	0	0	4	2.001
PPIs
8	6:02	62.0 ± 17.0	6	0	0	1	0	1	1.001

¹P < 0.05 vs both no anti-ulcer drugs and cytoprotective drugs, according to the Mann-Whitney U test.