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©2009 The WJG Press and Baishideng.
World J Gastroenterol. Nov 28, 2009; 15(44): 5525-5532
Published online Nov 28, 2009. doi: 10.3748/wjg.15.5525
Published online Nov 28, 2009. doi: 10.3748/wjg.15.5525
Table 1 Patient characteristics
Characteristics | Patients included (n = 74) |
Sex (male/female) | 32/42 |
Age (yr) | 55.32 ± 9.6 (31-72) |
BMI (kg/m2) | 25.59 ± 4.03 (17.23-33.29) |
AST (IU/L) | 50.06 ± 32.36 (18-188) |
ALT (IU/L) | 67.06 ± 26.79 (20-147) |
INR | 1.12 ± 0.15 (0.9-1.74) |
Bilirubin (mg/dL) | 0.69 ± 0.32 (0.29-2.08) |
Albumin (g/dL) | 3.9 ± 0.55 (2.6-4.9) |
Cholesterol (mg/dL) | 192.36 ± 46.58 (120-311) |
Triglycerides (mg/dL) | 123.24 ± 73.33 (48-467) |
Table 2 Patient distribution according to fibrosis stage, activity grade and steatosis
Fibrosis | Activity | Steatosis | |||
Stage | n (%) | Grade | n (%) | Grade | n (%) |
0 | 1 (1.3) | 0 | 1 (1.3) | 0 | 24 (32.4) |
1 | 9 (12.1) | 1 | 32 (43.2) | 1 | 23 (31.08) |
2 | 25 (33.7) | 2 | 29 (39.1) | 2 | 12 (16.2) |
3 | 19 (25.6) | 3 | 12 (16.2) | 3 | 11 (14.8) |
4 | 20 (27.02) | 4 | 4 (5.40) |
Table 3 Most discriminative cutoff values of ARFI elastography
≥F1 | ≥F2 | ≥F3 | F4 | |
Cutoff (m/s) | 1.185 | 1.215 | 1.54 | 1.94 |
Sensitivity (95% CI) | 89% (79-95) | 100% (91-100) | 97% (86-100) | 100% (83-100) |
Specificity (95% CI) | 87% (47-99) | 71% (53-85) | 100% (90-100) | 98% (90-99) |
PPV (95% CI) | 98% (91-99) | 79% (65-89) | 100% (90-100) | 95% (76-100) |
NPV (95% CI) | 50% (23-76) | 100% (86-100) | 97% (85-100) | 100% (93-100) |
Positive likelihood ratio | 7.1 | 3.5 | 3.5 | 54 |
Table 4 Noninvasive tests and their correlations with liver pathology
Noninvasive test | Correlation (Spearman coefficient) | 95% CI | P | |
Liver biopsy | Elastography ARFI | 0.919 | 0.872-0.949 | < 0.001 |
APRI index | 0.712 | 0.572-0.811 | < 0.001 | |
FibroMax | 0.674 | 0.521-0.784 | < 0.001 |
- Citation: Fierbinteanu-Braticevici C, Andronescu D, Usvat R, Cretoiu D, Baicus C, Marinoschi G. Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis. World J Gastroenterol 2009; 15(44): 5525-5532
- URL: https://www.wjgnet.com/1007-9327/full/v15/i44/5525.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.5525