Efficacy of surgical resection in management of isolated extrahepatic metastases of hepatocellular carcinoma

Table 1 Clinical characteristics of patients with extrahepatic metastases of hepatocellular carcinoma

Characteristics	n (%)
Age (yr)	55.8 ± 14.4
Male:Female	108:32
Hepatitis B virus surface antigen	66 (47)
Hepatitis C virus antibody	30 (21.4)
Previous hepatic resection
Yes	66 (47)
Single hepatic resection	57
Multiple hepatic resection	7
Liver transplantation	2
No	74 (53)
Location of metastatic tumor
Lung	25 (17.8)
Bone	47 (33.6)
Brain	28 (20)
Soft tissue	35 (25)
Heart	2 (1.4)

Table 2 Clinical characteristics of patients who underwent surgical resection of extrahepatic metastases of hepatocellular carcinoma

Characteristics	n (%)
Age (yr)	54.1 ± 14.9
Male:Female	64:22
Hepatitis B virus surface antigen	46 (53)
Hepatitis C virus antibody	22 (21.4)
Concurrent treated intrahepatic lesion
Yes	59 (69)
No	27 (31)
Location of metastatic tumor
Lung	11 (12.8)
Bone	24 (27.9)
Brain	25 (29.1)
Soft tissue	24 (27.9)
Heart	2 (2.3)

Table 3 Clinical features of patients who underwent surgical resection for extrahepatic metastases from HCC with favorable outcomes

No. ofpatient	Age (yr)/Sex	Treatments for intrahepatic HCC	Extrahepatic metastases		Follow-up after metastases (mo)	Outcome
			Duration to metastases (mo)	Location/Management
1	44/Male	Hepatic resection: 1 time	7	Lung/wedge resection	40	Alive
		TACE: 1 time
2	36/Female	Hepatic resection: 1 time	16	T-spine/resection of tumor	89	Dead
		TACE: 1 time		Lung/wedge resection
3	31/Female	Hepatic resection: 1 time	11	Transverse colon and peritoneal soft tissue/surgical resection	67	Alive
		TACE: 3 times
4	51/Male	Hepatic resection: 1 time	32	Peritoneal soft tissue/surgical resection	96	Alive
		TACE: 2 times
		PEI: 1 time
		RFA:1 time
5	67/Male	TACE: 11 times	7	Abdominal wall/wide excision	57	Dead
		PEI: 8 times