CDH1 promoter polymorphism (-347G→GA) is a possible prognostic factor in sporadic colorectal cancer

Table 1 Clinical characteristics of the CRC patients and normal controls

	CRC patients (%)	Normal controls (%)	P
Sex
Male	188 (64.8)	212 (63.3)
Female	102 (35.2)	123 (36.7)	0.6881
Age (yr)
Range	27-85	15-81
Mean	63.51 ± 13.24	58.62 ± 17.45	0.4072
Smoking history
Yes	117 (40.3)	122 (36.4)
No	173 (59.7)	213 (63.6)	0.3141
Drinking history
Yes	128 (44.1)	135 (40.3)
No	162 (55.9)	200 (59.7)	0.3321
Stage
Dukes A	12
Dukes B	89
Dukes C	102
Dukes D	87
Location
Ascending, transverse	138
Descending, sigmoid	61
Rectum	91
Total	290	335

¹Two-tailed χ²-test;

²Two-tailed t-test; CRC: Colorectal cancer.

Table 2 Distribution of the CDH1 -347G→GA polymorphism between CRC patients and normal controls

	G-allele (%)1	GA-allele (%)2	OR (95% CI)3	χ2	P
Controls	194 (57.9)	141 (42.1)
Patients	153 (52.8)	137 (47.2)	1.232 (0.898-1.691)	1.671	0.198
Sex
Male	98 (52.1)	90 (47.9)	1.264 (0.882-1.809)	1.633	0.233
Female	55 (53.9)	47 (46.1)	1.176 (0.753-1.836)	0.508	0.495
Age (yr)
> 60	95 (55.2)	77 (44.8)	1.115 (0.770-1.616)	0.333	0.571
≤ 60	58 (49.2)	60 (50.8)	1.423 (0.934-2.169)	2.712	0.107
Smoking
Yes	57 (48.7)	60 (51.3)	1.448 (0.949-2.210)	2.967	0.105
No	96 (55.5)	77 (44.5)	1.104 (0.762-1.598)	0.273	0.637
Drinking
Yes	66 (51.6)	62 (48.4)	1.292 (0.859-1.945)	1.516	0.249
No	87 (53.7)	75 (46.3)	1.186 (0.813-1.730)	0.786	0.386
Location
Proximal4	63 (45.7)	75 (54.3)	1.638 (1.099-2.441)	5.919	0.019
Distal5	90 (59.2)	62 (40.8)	0.948 (0.642-1.399)	0.073	0.843
Differentiation
Well	116 (56.3)	90 (43.7)	1.067 (0.752-1.516)	0.133	0.721
Poorly	16 (33.3)	32 (66.7)	2.752 (1.454-5.209)	10.240	0.002
Other	21 (58.3)	15 (41.7)	0.983 (0.489-1.974)	0.002	1.000
Stage
Dukes A/B	58 (57.4)	43 (42.6)	1.020 (0.650-1.600)	0.007	1.000
Dukes C/D	95 (50.3)	94 (49.7)	1.361 (0.951-1.948)	2.856	0.100

¹G/G homozygous;

²GA/GA homozygous; GA/G heterozygous;

³95% confidence interval;

⁴Ascending colon, transverse colon;

⁵Descending colon, sigmoid colon, rectum; CDH1: E-cadherin gene.