Celiac disease in patients with presumed irritable bowel syndrome: A case-finding study

Table 1 The modified Marsh classification of celiac disease

Type	Intraepithelial lymphocytes per 100 enterocytes	Crypts	Villi
0	< 40	Normal	Normal
1	> 40	Normal	Normal
2	> 40	Increased	Normal
3a	> 40	Increased	Mild atrophy
3b	> 40	Increased	Marked atrophy
3c	> 40	Increased	Absent

Table 2 The distribution of patients according to gender and IBS type n (%)

IBS type	Gender		Total
	Male	Female
C-IBS	140 (47.8)	217 (48.3)	357 (48.1)
D-IBS	84 (28.7)	122 (27.2)	206 (27.8)
C/D-IBS	69 (23.5)	110 (24.5)	179 (24.1)
Total	293	449	742

IBS: Irritable bowel syndrome; C-IBS: Constipation-predominant IBS; D-IBS: Diarrhea-predominant IBS; C/D-IBS: Alternating constipation-diarrhea IBS.

Table 3 The prevalence of celiac disease in different types of IBS patients

	No. of study patients	No. of celiac cases	Prevalence of CD (95% CI)
C-IBS	357	6	1.68 (0.35, 3.01)a
D-IBS	206	14	6.80 (3.36, 10.23)a
C/D-IBS	179	4	2.23 (0.07, 4.40)
Total	742	24	3.23 (1.96, 4.50)

^aSignificantly different (P-value = 0.0026); CI: Confidence interval.

Table 4 The demographic and clinical features of celiac disease patients

Variable	n (%)
Gender
Female	13 (54.2)
Male	11 (45.8)
Age (yr)
18-25	8 (33.3)
26-35	8 (33.3)
36-61	8 (33.3)
mean (SD)	33.5 (11.5)
Body mass index, mean (SD)	26.6 (3.5)
Duration of symptoms (mo), mean (SD)	26.8 (18.1)
IBS type
C-IBS	6 (25.0)
D-IBS	14 (58.3)
C/D-IBS	4 (16.7)
Malabsorptive features
Hypoalbuminemia	2 (8.3)
Hypocalcemia	2 (8.3)
Iron deficiency	4 (16.7)
None	16 (66.7)