Experimental evidence of obesity as a risk factor for severe acute pancreatitis

doi:10.3748/wjg.15.5260

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Nov 14, 2009 (publication date) through Oct 29, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2009; 15(42): 5260-5265
Published online Nov 14, 2009. doi: 10.3748/wjg.15.5260

Table 1 Severity of acute pancreatitis and adipokines

Adipocytokine	Effects	Final effect
Leptin	↑TNF-α	Pro-inflammatory
	↑Chemotaxis
	↑Neutrophil activation
	↑IL-6
	↑T-cell proliferation
Adiponectin	↓Endothelial cell adhesion	Anti-inflammatory
	↓TNF-α
	↓IL-6
	↓Phagocytosis
	↑IL-10
	↑IL-1RA

Adiponectin may be considered as an anti-inflammatory compound whereas leptin acts as a proinflammatory mediator. Both adipokines may influence the severity of pancreatitis.

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Citation: Frossard JL, Lescuyer P, Pastor CM. Experimental evidence of obesity as a risk factor for severe acute pancreatitis. World J Gastroenterol 2009; 15(42): 5260-5265
URL: https://www.wjgnet.com/1007-9327/full/v15/i42/5260.htm
DOI: https://dx.doi.org/10.3748/wjg.15.5260