High circulating N-terminal pro-brain natriuretic peptide and tumor necrosis factor-α in mixed cryoglobulinemia

Table 1 Demographic and clinico-serological features of 50 MC+HCV patients

Age (yr)	57 ± 9
Male/female	13/37
Disease duration with MC (yr)	10 ± 11
Purpura	82%
Active vasculitis	31%
Weakness	91%
Arthralgias	83%
Arthritis	14%
Raynaud’s phenomenon	51%
Sjogren’s syndrome	45%
Peripheral neuropathy	59%
Aminotransferase elevation and/or histologic activity1	71%
Cryocrit (%)	4.2 ± 8.9
CH50 (normal: 160-220 U)	111 ± 36
C3 (normal: 60-130 mg/dL)	81 ± 36
C4 (normal: 20-55 mg/dL)	14 ± 18
Autoantibodies2	25%

¹Increase of the liver enzyme (alanine aminotransferase) and/or liver histological alterations.

²Presence of anti-nuclear and/or anti-mitochondrial and/or anti-smooth muscle and/or anti-extractable nuclear antigen autoantibodies. MC+HCV: Hepatitis C associated with mixed cryoglobulinemia.