Clinical expression of insulin resistance in hepatitis C and B virus-related chronic hepatitis: Differences and similarities

Table 1 Epidemiological and histological data of the two groups studied

	HCV	HBV	P
Epidemiological data
Number of patients (M/F)	726 (426/300)	126 (83/43)	NS
DD (yr)	25.78 ± 14.22	21.4 ± 11.91	< 0.005
Age (yr)	53.88 ± 13.20	45.68 ± 14.40	< 0.0001
BMI (kg/m2)	26.74 ± 4.25	25.43 ± 3.43	< 0.005
Metabolic syndrome	76 pt (10.46%)	2 pt (1.72%)	< 0.005
Liver Biopsy (Ishak Score)
Grading	11.25 ± 3.50	6.61 ± 3.36	NS
Staging	2.66 ± 1.99	2.44 ± 1.57	NS
Steatosis > 30%	98 pt (13.49%)	14 pt (12.06%)	NS

Table 2 Univariate analysis (Spearman test) between liver fibrosis (Ishak staging on liver biopsy) and anthropometric, clinical and metabolic characteristics in the two groups of patients

	HCV				HBV
	Linearity coefficient	Standard error	P	t	Linearity coefficient	Standard error	P	t
Age (yr)	0.332	0.046	< 0.0001	7.377	0.532	0.071	< 0.0001	5.689
Sex	0.284	0.046	< 0.05	3.764	0.132	0.108	NS	1.209
BMI	0.243	0.050	< 0.0001	4.633	0.142	0.113	NS	1.162
ALT	0.227	0.045	< 0.0001	4.833	0.157	0.082	NS	1.435
Diabetes	0.211	0.050	< 0.0001	4.532	0.014	0.123	NS	0.103
Metabolic syndrome	0.108	0.039	< 0.05	2.278	0.015	0.011	NS	0.112
Steatosis	0.095	0.045	< 0.05	2.006	0.068	0.187	NS	0.283

Table 3 Multivariate analysis (multiple regression) of the correlation between liver fibrosis (Ishak staging on liver biopsy) and anthropometric, clinical and metabolic characteristics in the two groups of patients

	HCV			HBV
	Linearity coefficient	Standard error	P	Linearity coefficient	Standard error	P
Age (yr)	0.0469	0.0068	< 0.0001	0.0561	6.0142	0.0001
Sex	0.0362	0.1794	< 0.05	-	-	-
BMI	0.0417	0.0208	< 0.05	-	-	-
ALT	0.0038	0.0010	< 0.0001	-	-	-
Diabetes	0.4742	0.2172	< 0.05	-	-	-
Metabolic syndrome	0.2830	0.2846	NS	-	-	-
Steatosis	0.0731	0.2326	NS	-	-	-

Table 4 Univariate analysis of the correlation between the presence of higher degrees of steatosis (> 30%) assessed on liver biopsy and anthropometric, clinical and metabolic characteristics in the two groups of patients

	HCV			HBV
	OR	95% CI	P	OR	95% CI	P
Age (yr)	1.747	0.888-3.430	NS	4.432	1.056-18.310	< 0.05
Sex	0.845	0.551-1.294	NS	0.549	0.191-1.575	NS
BMI (> 30)	2.510	1.593-3.954	< 0.001	10.435	2.166-38.338	< 0.005
Diabetes	1.894	1.193-3.007	< 0.05	0.913	0.213-4.017	NS
Metabolic syndrome	0.968	0.486-1.931	NS	4.180	0.531-3.367	NS
Fibrosis (staging)	4.700	2.750-8.034	< 0.001	0.459	0.073-2.981	NS

Table 5 Multivariate analysis (logistic regression) of the correlation between the presence of significant steatosis (> 30%) assessed on liver biopsy and anthropometric, clinical and metabolic characteristics in the two groups of patients

	HCV			HBV
	OR	95% CI	P	OR	95% CI	P
Age (yr)	-	-	-	1.214	1.085-1.359	< 0.001
BMI (> 30)	2.216	1.186-4.143	< 0.05	1.049	1.007-1.094	< 0.05
Diabetes	2.684	1.444-4.987	< 0.005	-	-	-
Fibrsis (Staging)	4.700	2.750-8.034	< 0.001	-	-	-