A new polymorphism in the GRP78 is not associated with HBV invasion

Table 1 Characterization of the participants (mean ± SD) n (%)

Characteristics	Cases	Controls	P
Age (yr)	30.5 ± 7.2	27.8 ± 7.0	0.4261
Gender
Females	149 (39.01)	147 (42.00)
Males	233 (60.99)	203 (58.00)	0.4102
ALT (U/L)	125.5 ± 81.7	28.2 ± 10.9
HBsAg (+)	382 (100)	0
Anti-HBs	0	0
HBeAg (+)	134 (35.07)	0
Anti-HBe	248 (64.93)	0

¹Mann-Whitney test;

²Pearson χ² test. ALT: Alanine aminotransferase.

Table 2 Allele and genotype frequencies of the new SNP (-86 bp T > A) in GRP78 among cases and controls, and risk of HBV n (%)

Allele/genotype	Cases	Controls	OR1 (95% CI)	P1
T	749 (98.1)	689 (98.5)	Reference
A	15 (1.9)	11 (1.5)	1.24 (0.56-2.78)	0.534
TT	367 (96.1)	339 (96.8)	Reference
AT	15 (3.9)	11 (3.2)	1.25 (0.57-2.80)	0.529
AA	0	0

¹The data were calculated by logistic regression with adjusted for age and gender. OR: Odds ratio; CI: Confidence interval; HBV: Hepatitis B virus; SNP: Single-nucleotide polymorphism.

Table 3 ORs and 95% CIs calculated by logistic regression with adjustment for age and gender between different case subgroups according to the alleles and genotypes of the new SNP (-86 bp T > A) in all HBV carriers

Alleles/genotypes	Serum ALT				Serum HBeAg
	> 40 IU/L (n)	≤40 IU/L (n)	OR (95% CI)	P1	+ (n)	- (n)	OR (95% CI)	P2
T	194	555	Reference		266	483	Reference
A	2	13	0.45 (0.10-1.99)	0.262	2	13	0.28 (0.06-1.25)	0.076
TT	96	271	Reference		132	235	Reference
AT	2	13	0.44 (0.10-1.97)	0.254	2	13	0.29 (0.06-1.23)	0.070
AA	0	0			0	0

¹P values for ALT > 40 IU/L cases vs ALT ≤ 40 IU/L cases; ²P values for HBeAg positive cases vs HBeAg negative cases. +: Positive; -: Negative.